Promruck Natchanon, Ruengorn Chidchanok, Thavorn Kednapa, Bandhaya Panwadee, Nochaiwong Surapon
Faculty of Dentistry, Department of Restorative Dentistry and Periodontology, Chiang Mai University, Chiang Mai, Thailand.
Pharmacoepidemiology and Statistical Research Center, Chiang Mai University, Chiang Mai, Thailand.
SAGE Open Med. 2024 Oct 16;12:20503121241290385. doi: 10.1177/20503121241290385. eCollection 2024.
Although epidemiological studies suggest that oral health conditions may be associated with an increased risk of noncommunicable diseases, the findings have yet to be comprehensively synthesized, particularly for a major noncommunicable diseases-related health and economic burden. Therefore, we will perform a systematic review and meta-analysis of all available observational studies investigating the association between oral health conditions and subsequent risk of major noncommunicable diseases.
With limited English publications, we will search electronic databases, including MEDLINE, Embase, PubMed, Cochrane Library, Scopus, and CINAHL. Based on the temporal properties and natural course of disease progression, we will seek cohort or case-control studies that investigate the association between oral disease conditions and the risk of noncommunicable diseases. Regarding the World Health Organization agenda, oral health conditions will include dental caries, periodontal disease, oral cancer, edentulism, other oral conditions (i.e., oro-dental trauma, cleft lip and palate, and noma), and endodontic lesions. Based on the global disease burden, primary outcomes of interest will include the four major systemic noncommunicable diseases: cardiovascular diseases, cancers, chronic respiratory diseases, and type 2 diabetes mellitus. Random-effects meta-analysis will be used to estimate pooled effects estimate and 95% confidence intervals. Statistical heterogeneity will be investigated using the index and statistics. Preplanned subgroup and sensitivity analyses and random-effects meta-regression analyses will be performed to address possible heterogeneity and establish the robustness of the meta-analytic estimates. The prediction intervals, expected ()-value, and evidence certainty will be appraised to synthesize the findings and draw evidence-based conclusions.
This systematic review will summarize all available evidence regarding the association between oral health conditions and the risk of major noncommunicable diseases. The findings will encourage collaboration between oral health and primary care professionals for early detection and management of noncommunicable diseases and promote oral health well-being.
PROSPERO: CRD42021274184.
尽管流行病学研究表明口腔健康状况可能与非传染性疾病风险增加有关，但这些研究结果尚未得到全面综合，特别是对于与主要非传染性疾病相关的健康和经济负担而言。因此，我们将对所有现有的观察性研究进行系统评价和荟萃分析，以调查口腔健康状况与主要非传染性疾病后续风险之间的关联。
由于英文出版物有限，我们将检索电子数据库，包括MEDLINE、Embase、PubMed、Cochrane图书馆、Scopus和CINAHL。基于疾病进展的时间特性和自然病程，我们将寻找队列研究或病例对照研究，以调查口腔疾病状况与非传染性疾病风险之间的关联。根据世界卫生组织议程，口腔健康状况将包括龋齿、牙周病、口腔癌、无牙症、其他口腔状况（即口腔牙外伤、唇腭裂和坏疽性口炎）以及牙髓病变。基于全球疾病负担，感兴趣的主要结局将包括四种主要的全身性非传染性疾病：心血管疾病、癌症、慢性呼吸道疾病和2型糖尿病。随机效应荟萃分析将用于估计合并效应估计值和95%置信区间。将使用I²指数和Q统计量调查统计异质性。将进行预先计划的亚组分析、敏感性分析和随机效应荟萃回归分析，以解决可能的异质性并确定荟萃分析估计值的稳健性。将评估预测区间、预期的（）值和证据确定性，以综合研究结果并得出基于证据的结论。
本系统评价将总结关于口腔健康状况与主要非传染性疾病风险之间关联的所有现有证据。这些发现将鼓励口腔健康和初级保健专业人员之间的合作，以便早期发现和管理非传染性疾病，并促进口腔健康福祉。
PROSPERO：CRD42021274184。
