Nguyen Lam Van, Nguyen Duc Sy, Pham Que Thi, Do Hai Thien, Tran Dien Minh, Cao Tung Viet, Phan Hai Thanh, Pham Thai Quang
Vietnam National Children's Hospital, Hanoi, Vietnam.
Hanoi Medical University, Hanoi, Vietnam.
Glob Pediatr Health. 2024 Oct 11;11:2333794X241286549. doi: 10.1177/2333794X241286549. eCollection 2024.
. This study aims to report clinical features and treatment outcomes of 16 cases diagnosed with post-influenza encephalopathy/encephalitis. . We recorded clinical characteristics of 16 pediatric patients diagnosed with post-influenza encephalopathy/encephalitis at the Vietnam National Children's Hospital from January 2019 to January 2021. . There were 87.5% infected with influenza A, with influenza A/H1pdm09 and influenza A/H3 accounting for 88.9% and 11.1% respectively, and 12.5% of participants infected with influenza B. The time from onset to the appearance of neurological symptoms was 3 days, of which perceptual changes (93.8%), hypertonia (75%), and seizures (43.8%) were prevalent neurological symptoms. The majority of cases had normal cerebrospinal fluid. Cranial CT/MRI imaging revealed abnormalities in 87.5% of patients. 56.3% of patients had sequelae, including epilepsy and cerebral palsy; 25% recovered, and 18.8% died after treatment. . Influenza-associated encephalitis/encephalopathy is a complication occurring early in children, with high mortality and sequelae rates.
本研究旨在报告16例确诊为流感后脑病/脑炎的临床特征及治疗结果。我们记录了2019年1月至2021年1月在越南国家儿童医院确诊为流感后脑病/脑炎的16例儿科患者的临床特征。87.5%的患者感染甲型流感，其中甲型H1N1pdm09流感和甲型H3流感分别占88.9%和11.1%，12.5%的参与者感染乙型流感。从发病到出现神经症状的时间为3天，其中感知改变（93.8%）、肌张力亢进（75%）和癫痫发作（43.8%）是常见的神经症状。大多数病例的脑脊液正常。头颅CT/MRI成像显示87.5%的患者有异常。56.3%的患者有后遗症，包括癫痫和脑瘫；25%的患者康复，18.8%的患者治疗后死亡。流感相关的脑炎/脑病是儿童早期发生的一种并发症，死亡率和后遗症发生率很高。
