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维生素 D 补充剂可减少儿童哮喘发作：随机对照试验的系统评价和荟萃分析。

Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.

机构信息

Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.

Department of Child Health, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia.

出版信息

Ann Med. 2024 Dec;56(1):2400313. doi: 10.1080/07853890.2024.2400313. Epub 2024 Oct 18.

DOI:10.1080/07853890.2024.2400313
PMID:39421966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11492411/
Abstract

BACKGROUND

Observational studies have linked low vitamin D (VD) levels to increased asthma attacks in children. Subsequent meta-analyses of adults and children revealed that VD treatment might benefit asthmatic patients by reducing the incidence of exacerbations. Therefore, this review aims to analyze the effects of VD supplementation in reducing asthma exacerbations in children.

METHODS

Published reports from PubMed, Cochrane, and Google Scholar were systematically searched until April 2023. The study protocol was registered in the PROSPERO database CRD42023411796. Randomized controlled trial studies were included in this review. Meta-analysis was performed using Cochrane RevMan 5.1 and presented with 95% confidence intervals (CIs).

RESULTS

Ten relevant studies enrolled 1243 asthmatic children (631 children receiving vitamin D3 supplementation, 612 children receiving placebo) were included in this review. Our pooled analysis found that VD supplementation had a significant effect on lowering the total number of asthma exacerbations (RR 0.62; 95% CI: 0.44, 0.87;  = 0.01). Subgroup analysis revealed that a daily dose of VD given based on standard daily dose recommendation had a significant improvement on asthma exacerbations [(RR 0.41; 95% CI: 0,18, 0,92;  = 0.03).

CONCLUSIONS

Vitamin D supplementation can lower the occurrence of exacerbations in children with asthma, along with the improvement of FEV1.

摘要

背景

观察性研究表明，维生素 D（VD）水平低与儿童哮喘发作增加有关。随后对成人和儿童的荟萃分析显示，VD 治疗可能通过降低加重的发生率使哮喘患者受益。因此，本综述旨在分析 VD 补充在减少儿童哮喘加重方面的作用。

方法

系统检索了 PubMed、Cochrane 和 Google Scholar 上发表的报告，检索截止日期为 2023 年 4 月。该研究方案已在 PROSPERO 数据库 CRD42023411796 中注册。本综述纳入了随机对照试验研究。使用 Cochrane RevMan 5.1 进行荟萃分析，并呈现 95%置信区间（CI）。

结果

纳入了 10 项相关研究，共纳入 1243 名哮喘儿童（631 名接受维生素 D3 补充，612 名接受安慰剂）。我们的汇总分析发现，VD 补充对降低哮喘加重总数有显著影响（RR 0.62；95%CI：0.44，0.87； = 0.01）。亚组分析显示，根据标准日剂量推荐给予的每日 VD 剂量对哮喘加重有显著改善作用[（RR 0.41；95%CI：0，18，0，92； = 0.03）。

结论

VD 补充可以降低哮喘儿童发作的发生频率，并改善 FEV1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c38/11492411/2da11d9aa7b0/IANN_A_2400313_F0009_C.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c38/11492411/e12a3c72fe57/IANN_A_2400313_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c38/11492411/6ec3c17e0d77/IANN_A_2400313_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c38/11492411/912a9d0c9df5/IANN_A_2400313_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c38/11492411/2da11d9aa7b0/IANN_A_2400313_F0009_C.jpg

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