Department of Respiratory Disease, Fujian Geriatric Hospital, Fuzhou 350003, China.
Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Biomed Res Int. 2020 Jan 27;2020:2940296. doi: 10.1155/2020/2940296. eCollection 2020.
Differences between early-onset and late-onset asthma in elderly subjects have not been comprehensively described in China. We conducted a cross-sectional study to determine the phenotypic differences between early-onset asthma (EOA) and late-onset asthma (LOA) in elderly patients. We collected clinical and physiological data from 176 elderly patients with asthma. Participants were divided into two groups: EOA group and LOA group. Demographics, comorbidities, inflammatory parameters, lung function, severity, asthma control, and medication use among EOA and LOA elderly patients were compared. Elderly subjects with EOA had more atopic disease, a stronger positive family history of asthma, higher IgE, and exhaled nitric oxide levels as compared to those with LOA. In contrast, elderly subjects with LOA had lower lung function and more marked fixed airflow obstruction (FAO). Elderly subjects with LOA had a higher incidence of chronic obstructive pulmonary disease (COPD). No differences were observed in age, gender, BMI, history of smoking, severity, and asthma control between the two groups. Both similarities and differences exist between elderly subjects with EOA and those with LOA in China. Further work is required to determine the pathophysiological, clinical, and therapeutic implications for different asthma phenotypes in elderly subjects.
在中国，尚未全面描述老年患者中早发性哮喘和晚发性哮喘之间的差异。我们进行了一项横断面研究，以确定老年患者中早发性哮喘（EOA）和晚发性哮喘（LOA）之间的表型差异。我们从 176 名老年哮喘患者中收集了临床和生理数据。参与者分为两组：EOA 组和 LOA 组。比较了 EOA 和 LOA 老年患者的人口统计学，合并症，炎症参数，肺功能，严重程度，哮喘控制和药物使用情况。与 LOA 相比，EOA 老年患者具有更多的特应性疾病，更强的哮喘阳性家族史，更高的 IgE 和呼气一氧化氮水平。相比之下，LOA 老年患者的肺功能更低，并且更明显的固定气流阻塞（FAO）。LOA 老年患者患有慢性阻塞性肺疾病（COPD）的发生率更高。两组之间在年龄，性别，BMI，吸烟史，严重程度和哮喘控制方面无差异。中国的 EOA 和 LOA 老年患者之间既有相似之处，也有不同之处。需要进一步研究不同哮喘表型在老年患者中的病理生理，临床和治疗意义。
