Hou Chaoqun, Wei Nuo, Liang Qianwei, Tan Yifei, Li Xiang, Feng Jianguo
College of Plant Protection, Yangzhou University, Yangzhou, China.
Pest Manag Sci. 2025 Feb;81(2):798-808. doi: 10.1002/ps.8483. Epub 2024 Oct 18.
Metal-organic frameworks have the advantages of easy synthesis, high loading capacity and good biocompatibility, making them essential materials for constructing pesticide nano-delivery systems. In this study, a pH-responsive nano-controlled-release formulation Chl@UiO-66 was prepared using UiO-66 as the nano-scale carrier for adsorbing chlorantraniliprole (Chl).
The appearance, pesticide loading, release behaviour, insecticidal activity, long-term control efficacy and safety of Chl@UiO-66 for non-target organisms were extensively evaluated. The results showed that the prepared Chl@UiO-66 was a regular octahedron with a uniform particle size of 230 nm and pesticide loading of 15.62%. The release of pesticides under alkaline conditions was superior to that under acidic and neutral conditions, which showed pH-responsive performance. Chl@UiO-66 had an excellent ability to protect pesticides from ultraviolet degradation. Compared with chlorantraniliprole suspension concentrate, Chl@UiO-66 had a better control effect against Spodoptera frugiperda and long-term control efficacy. The prepared nano-controlled-release formulation had low toxicity to zebrafish, earthworms and human BEAS-2B cells.
Chl@UiO-66 is a new pesticide formulation with high efficacy and low toxicity that provides a smart controlled-release solution. © 2024 Society of Chemical Industry.
金属有机框架材料具有合成简便、负载量高和生物相容性好等优点，使其成为构建农药纳米递送系统的重要材料。本研究以UiO-66为纳米载体吸附氯虫苯甲酰胺（Chl），制备了一种pH响应型纳米控释制剂Chl@UiO-66。
对Chl@UiO-66的外观、农药负载量、释放行为、杀虫活性、长期防治效果及对非靶标生物的安全性进行了广泛评估。结果表明，制备的Chl@UiO-66为规则八面体，粒径均匀，为230 nm，农药负载量为15.62%。农药在碱性条件下的释放优于酸性和中性条件，表现出pH响应性能。Chl@UiO-66具有优异的保护农药免受紫外线降解的能力。与氯虫苯甲酰胺悬浮剂相比，Chl@UiO-66对草地贪夜蛾的防治效果和长期防治效果更好。制备的纳米控释制剂对斑马鱼、蚯蚓和人BEAS-2B细胞毒性较低。
Chl@UiO-66是一种高效低毒的新型农药制剂，提供了一种智能控释解决方案。© 2024化学工业协会。
