Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
J Leukoc Biol. 2024 Nov 27;116(6):1291-1300. doi: 10.1093/jleuko/qiae230.
Historically, the nervous and immune systems were studied as separate entities. The nervous system relays signals between the body and the brain by processing sensory inputs and executing motor outputs, whereas the immune system provides protection against injury and infection through inflammation. However, recent developments have demonstrated that these systems mount tightly integrated responses. In particular, the peripheral nervous system acts in concert with the immune system to control reflexes that maintain and restore homeostasis. Notwithstanding their homeostatic mechanisms, dysregulation of these neuroimmune interactions may underlie various pathological conditions. Understanding how these two distinct systems communicate is an emerging field of peripheral neuroimmunology that promises to reveal new insights into tissue physiology and identify novel targets to treat disease.
从历史上看，神经系统和免疫系统是作为两个独立的实体进行研究的。神经系统通过处理感觉输入和执行运动输出，在身体和大脑之间传递信号，而免疫系统通过炎症提供对损伤和感染的保护。然而，最近的发展表明，这些系统会产生紧密结合的反应。特别是，外周神经系统与免疫系统协同作用，控制维持和恢复体内平衡的反射。尽管它们有体内平衡机制，但这些神经免疫相互作用的失调可能是各种病理状况的基础。了解这两个截然不同的系统如何进行通信是外周神经免疫学的一个新兴领域，有望揭示组织生理学的新见解，并确定治疗疾病的新靶点。
