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INTRODUCTION

Hemorrhagic shock requires immediate treatment to prevent mortality and organ dysfunction. This study evaluates the efficacy of methylene blue (MB) with blood transfusion (BT) as a potential rescue therapy in acute severe bleeding in pigs.

METHODS

Thirty animals were randomly assigned to one of six groups following the induction of fixed-pressure hemorrhagic shock, after reaching a mean arterial pressure (MAP) of 55 mmHg - Group 1 (60 BT: BT after 60 minutes), Group 2 (60 MB: MB infusion after 60 minutes), Group 3 (60 MB + BT: MB and BT after 60 minutes), Group 4 (15 MB + BT: MB and BT after 15 minutes), Group 5 (15 BT + 60 MB: BT after 15 minutes and MB infusion after 60 minutes), and Group 6 (15 MB + 60 BT: MB infusion after 15 minutes and BT after 60 minutes). Hemodynamic and blood gas parameters were meticulously recorded, reversal of the shock was considered when MAP reached 90% of the baseline MAP.

RESULTS

Except for Group 2, all groups reverted from the shock. However, groups that received MB in combination with BT, specifically Groups 3 and 4, exhibited statistically significant higher ratios of maximum MAP to baseline MAP.

CONCLUSION

Using MB concomitant with BT allowed the reversal of hemorrhagic shock with higher median arterial pressure levels compared to BT alone or applying MB separately from BT. This suggests that simultaneous application of MB and BT could be a more effective strategy for reversing the effects of severe acute bleeding.

INTRODUCTION

METHODS

RESULTS

CONCLUSION

简介

失血性休克需要立即治疗，以防止死亡和器官功能障碍。本研究评估了亚甲蓝（MB）联合输血（BT）作为猪急性严重出血潜在抢救治疗的疗效。

方法

30 只动物在诱导固定压力失血性休克后，在平均动脉压（MAP）降至 55mmHg 后随机分为六组之一 - 组 1（60 BT：60 分钟后输血），组 2（60 MB：60 分钟后输注 MB），组 3（60 MB + BT：60 分钟后同时输注 MB 和 BT），组 4（15 MB + BT：15 分钟后同时输注 MB 和 BT），组 5（15 BT + 60 MB：15 分钟后输血，60 分钟后输注 MB），组 6（15 MB + 60 BT：15 分钟后输注 MB，60 分钟后输血）。精心记录血流动力学和血气参数，当 MAP 达到基线 MAP 的 90%时，认为休克逆转。