Wikman-Coffelt J, Sievers R, Parmley W W, Jasmin G
Am J Physiol. 1986 Jan;250(1 Pt 2):H22-8. doi: 10.1152/ajpheart.1986.250.1.H22.
There is a decrease in total adenine nucleotides, cyclic AMP (cAMP), ATP/total ADP, and phosphocreatine (PCr)/creatine (Cr) both in situ and in the perfused heart in the heart failure stage of the cardiomyopathic Syrian hamster. There were decreases in developed pressure, dP/dt, and O2 consumption associated with the decrease in total adenine nucleotides and cAMP. Cardiomyopathic Syrian hamsters (180-240 days old) with congestive heart failure were given water with the calcium entry blocker, verapamil, as an additive 2 mo before death. In the cardiomyopathic group given verapamil the adenine nucleotides, cAMP, and high-energy phosphates were preserved and cardiac performance was not significantly different from that of the verapamil-treated healthy hamsters at the time of death. Pretreatment of cardiomyopathic animals with verapamil (6.6 mg verapamil/ml water consumed by drinking) resulted in significantly higher ATP/total ADP and PCr/Cr compared with nontreated cardiomyopathic hamsters. This is the first report demonstrating that a calcium entry blocker may improve cardiac performance and preserve total adenine nucleotides during the heart failure stage of the cardiomyopathic hamster.
在患心肌病的叙利亚仓鼠的心力衰竭阶段，原位心脏和灌注心脏中的总腺嘌呤核苷酸、环磷酸腺苷（cAMP）、ATP/总ADP以及磷酸肌酸（PCr）/肌酸（Cr）均减少。与总腺嘌呤核苷酸和cAMP的减少相关，心脏的舒张末期压力、dP/dt以及耗氧量均降低。在死亡前2个月，给患有充血性心力衰竭的180 - 240日龄患心肌病的叙利亚仓鼠饮用添加了钙通道阻滞剂维拉帕米的水。在给予维拉帕米的心肌病组中，腺嘌呤核苷酸、cAMP和高能磷酸盐得以保留，并且在死亡时心脏功能与经维拉帕米治疗的健康仓鼠相比无显著差异。与未治疗的患心肌病仓鼠相比，用维拉帕米（饮用的水中含6.6 mg维拉帕米/ml）对患心肌病动物进行预处理可使ATP/总ADP和PCr/Cr显著升高。这是首次有报告表明钙通道阻滞剂可在患心肌病仓鼠的心力衰竭阶段改善心脏功能并保留总腺嘌呤核苷酸。
