Niimi Aya, Akiyama Yoshiyuki, Tomonori Yamanishi, Furuta Akira, Matsuo Tomohiro, Tomoe Hikaru, Kakizaki Hidehiro, Matsukawa Yoshihisa, Ogawa Teruyuki, Mitsui Takahiko, Masumori Naoya, Inamura So, Enomoto Yutaka, Nomiya Akira, Maeda Daichi, Igawa Yasuhiko, Kume Haruki, Homma Yukio
Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Urology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Int J Urol. 2025 Jan;32(1):103-109. doi: 10.1111/iju.15603. Epub 2024 Oct 18.
To describe clinical manifestations of patients with interstitial cystitis and bladder pain syndrome (IC/BPS) using a patient registry in Japan.
This retrospective cohort study utilized a patient registry supported by the Japanese Ministry of Health, Labor, and Welfare. Patients were classified as IC or BPS based on cystoscopic findings. Data on demographics, comorbidities, symptom severity, pain intensity, and bladder function were collected and we evaluated the differences in clinical characteristics between IC and BPS, and used multivariate analysis to search for additional factors that might contribute to pain.
A data set comprising 529 patients was obtained from 14 university hospitals. 66.5% of the cases were classified as IC and 33.5% as BPS. IC patients were significantly aged and female-dominant. Comorbidities such as autoimmune diseases were more prevalent in IC patients. All of the symptom severity, quality of life impairment, and bladder function were significantly worse in patients with IC. Urinary frequency and maximum voided volume on the Frequency-volume chart were 18.8 times and 15.0 times, and 160.9 and 214.1 mL, respectively. Bladder capacity under anesthesia was 293.8 and 472.6 mL, respectively. Maximum voided volume and the number of Hunner lesions were significant predictors of pain in IC patients.
The analysis revealed clinical manifestations of IC/BPS using the largest cohort in Japan. The results indicated higher age, higher female proportion, and higher symptomatic and functional severity in IC patients compared to BPS.
利用日本的患者登记系统描述间质性膀胱炎和膀胱疼痛综合征（IC/BPS）患者的临床表现。
这项回顾性队列研究利用了日本厚生劳动省支持的患者登记系统。根据膀胱镜检查结果将患者分为IC或BPS。收集了人口统计学、合并症、症状严重程度、疼痛强度和膀胱功能的数据，我们评估了IC和BPS之间临床特征的差异，并使用多变量分析寻找可能导致疼痛的其他因素。
从14家大学医院获得了一个包含529名患者的数据集。66.5%的病例被分类为IC，33.5%为BPS。IC患者年龄较大且以女性为主。自身免疫性疾病等合并症在IC患者中更为普遍。IC患者的所有症状严重程度、生活质量损害和膀胱功能均明显更差。频率-容量图上的排尿频率和最大排尿量分别为18.8次和15.0次，以及160.9和214.1毫升。麻醉下的膀胱容量分别为293.8和472.6毫升。最大排尿量和Hunner病变数量是IC患者疼痛的重要预测因素。
该分析揭示了日本最大队列的IC/BPS的临床表现。结果表明，与BPS相比，IC患者年龄更大、女性比例更高、症状和功能严重程度更高。
