Robinson P J, Rapoport S I
Am J Physiol. 1986 Jan;250(1 Pt 2):R127-36. doi: 10.1152/ajpregu.1986.250.1.R127.
A model is proposed for the uptake and metabolism of cold and radiotracer glucose that takes into account the concentration profiles of the cold and tracer glucose as they pass through the capillary bed of the brain. The model incorporates capillary blood flow, nonlinear transport between blood and brain, and Michaelis-Menten kinetics for incorporation of glucose into the brain metabolic pool. Analytical equations are derived for the conditions of normoglycemia and hypoglycemia. In normoglycemia, cold glucose uptake is determined solely by metabolic demand and is relatively independent of fluctuations in plasma glucose levels. At lower glucose levels, transport of glucose across the blood-brain barrier becomes a progressively more important factor in determining uptake. Uptake of radiotracer glucose depends primarily on transport parameters. Functional heterogeneity of the capillary bed is considered both in relation to glucose uptake and parameter estimation.
提出了一个关于冷葡萄糖和放射性示踪葡萄糖摄取与代谢的模型，该模型考虑了冷葡萄糖和示踪葡萄糖在通过脑毛细血管床时的浓度分布情况。该模型纳入了毛细血管血流量、血液与脑之间的非线性转运以及葡萄糖纳入脑代谢池的米氏动力学。推导了正常血糖和低血糖情况下的解析方程。在正常血糖状态下，冷葡萄糖摄取仅由代谢需求决定，且相对独立于血浆葡萄糖水平的波动。在较低葡萄糖水平时，葡萄糖跨血脑屏障的转运在决定摄取方面逐渐成为一个更为重要的因素。放射性示踪葡萄糖的摄取主要取决于转运参数。毛细血管床的功能异质性在葡萄糖摄取和参数估计方面均予以考虑。
