Spillert C R, Suval W D, Vernese N A, Lazaro E J
Am Surg. 1986 Jan;52(1):56-8.
Since the microcirculation is impaired in diabetes and since burn injury is associated with microvascular thrombosis, the purpose of this study was to determine whether diabetes increases the severity of burns. Swiss white mice were made diabetic with alloxan, and control animals received saline. One week later, animals with over 2000 mg/dl urine sugar and the control animals were anesthetized and burned uniformly on the back with a steel disc at 100 C for 10 sec. At 24 hr, burn severity was evaluated on a scale of 0 to 4 using gross and microscopic criteria. The mean burn severity of the diabetic mice was 0.80 +/- .15 and that of the control mice was 3.22 +/- .09 at 24 hr (P less than 0.001.). At 5 days, the differences of the burn severity between the two groups were still significant, but 5/10 (50%) of the diabetic mice and none of the control mice died. In diabetic mice, through burn severity appears mild in the wound, the mortality is high. Therefore, the criteria for initial evaluation of the diabetic with burns need to be reassessed.
由于糖尿病会导致微循环受损，且烧伤与微血管血栓形成有关，本研究的目的是确定糖尿病是否会加重烧伤的严重程度。用四氧嘧啶使瑞士小白鼠患糖尿病，对照动物注射生理盐水。一周后，对尿糖超过2000mg/dl的动物和对照动物进行麻醉，并用一个100℃的钢盘在其背部均匀烧伤10秒。24小时后，使用大体和显微镜标准按0至4的等级评估烧伤严重程度。糖尿病小鼠在24小时时的平均烧伤严重程度为0.80±0.15，对照小鼠为3.22±0.09（P<0.001）。5天时，两组之间的烧伤严重程度差异仍然显著，但糖尿病小鼠中有5/10（50%）死亡，对照小鼠无一死亡。在糖尿病小鼠中，尽管伤口处的烧伤严重程度看似较轻，但死亡率很高。因此，需要重新评估对烧伤糖尿病患者的初始评估标准。
