Bahrami Mehran, Khonakdar Hanieh, Moghaddam Armaghan, Mahand Saba Nemati, Bambizi Poorya Esmaili, Kruppke Benjamin, Khonakdar Hossein Ali
Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA 18015, USA.
Department of Polymer Processing, Iran Polymer and Petrochemical Institute, Tehran 14965-115, Iran.
Prog Biophys Mol Biol. 2024 Dec;194:16-33. doi: 10.1016/j.pbiomolbio.2024.10.001. Epub 2024 Oct 17.
This review dives into the complex dynamics of bone remodeling, combining biological insights with mathematical perspectives to better understand this fundamental aspect of skeletal health. Bone, being a crucial part of our body, constantly renews itself, and with the growing number of individuals facing bone-related issues, research in this field is vital. In this review, we categorized and classified most common mathematical models used to simulate the mechanical behavior of bone under different loading and health conditions, shedding light on the evolving landscape of bone biology. While current models have effectively captured the essence of healthy bone remodeling, the ever-expanding knowledge in bone biology suggests an update in mathematical methods. Knowing the role of the skeleton in whole-body physiology, and looking at the recent discoveries about activities of bone cells emphasize the urgency of refining our mathematical descriptions of the bone remodeling process. The underexplored impact of bone diseases like osteoporosis, Paget's disease, or breast cancer on bone remodeling also points to the need for intensified research into diverse disease types and their unique effects on bone health. By reviewing a range of bone remodeling models, we show the necessity for tailor-made mathematical models to decipher their roots and enhance patient treatment strategies. Collaboration among scientists from various domains is pivotal to surmount these challenges, ensuring improved accuracy and applicability of mathematical models. Ultimately, this effort aims to deepen our understanding of bone remodeling processes and their broader implications for diverse health conditions.
本综述深入探讨了骨重塑的复杂动态过程，将生物学见解与数学观点相结合，以更好地理解骨骼健康这一基本方面。骨骼作为我们身体的重要组成部分，不断进行自我更新，并且随着面临骨骼相关问题的个体数量不断增加，该领域的研究至关重要。在本综述中，我们对用于模拟不同负荷和健康状况下骨骼力学行为的最常见数学模型进行了分类，揭示了骨生物学不断演变的格局。虽然当前模型有效地捕捉到了健康骨重塑的本质，但骨生物学领域不断扩展的知识表明数学方法需要更新。了解骨骼在全身生理学中的作用，以及审视关于骨细胞活动的最新发现，凸显了完善我们对骨重塑过程数学描述的紧迫性。骨质疏松症、佩吉特病或乳腺癌等骨疾病对骨重塑的影响尚未得到充分探索，这也表明需要加强对各种疾病类型及其对骨骼健康独特影响的研究。通过回顾一系列骨重塑模型，我们展示了定制数学模型以解读其根源并改进患者治疗策略的必要性。来自各个领域的科学家之间的合作对于克服这些挑战至关重要，确保数学模型具有更高的准确性和适用性。最终，这项工作旨在加深我们对骨重塑过程及其对各种健康状况更广泛影响的理解。
