Li Jianxiang, Yang Hong, Cai Yongwei, Gu Ronghua, Chen Yao, Wang Yimeng, Dong Yuhang, Zhao Qi
School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China.
School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China.
Int J Biol Macromol. 2024 Dec;282(Pt 1):136405. doi: 10.1016/j.ijbiomac.2024.136405. Epub 2024 Oct 16.
The prevention of catheter-associated urinary tract infections (CAUTIs) significantly impacts the reduction of morbidity and mortality associated with the use of indwelling urinary catheters. This study focused on developing an antibacterial double network hydrogel coating for latex urinary catheters, which incorporated Ag quantum dots (Ag QDs) in a polyvinyl alcohol (PVA)-chitosan (CS) double network hydrogel matrix. The PVA-CS-Ag QDs, referred to as the PCA hydrogel coating exhibited excellent mechanical and physiochemical properties with controlled release of Ag QDs. The antibacterial properties of the PCA hydrogel-coated urinary catheters were studied against both gram-negative Escherichia coli (E. coli, ATCC25922) and gram-positive Staphylococcus aureus (S. aureus, ATCC29213). The continuous release of CS oligomers and Ag QDs from the hydrogel coating contributed to the synergistic antibacterial and antiadhesion effects. Measurements of the Ag release rate revealed that even after 30 days, the concentration of Ag QDs from the PCA hydrogel-coated urinary catheters remained significantly higher than the effective antibacterial concentration of the total Ag (0.1 μg·L). These results indicated that the PCA hydrogel coating not only efficiently prevented bacteria attachment, but also exhibited long-term antibacterial activity, thereby inhibiting biofilm formation. Furthermore, the PCA hydrogel-coated urinary catheter demonstrated excellent biocompatibility and hemocompatibility. Overall, this novel PCA hydrogel-coated urinary catheter, with its exceptional antibacterial properties, holds great potential in reducing the incidence of CAUTIs.
预防导尿管相关尿路感染（CAUTIs）对降低与留置导尿管使用相关的发病率和死亡率具有重大影响。本研究聚焦于为乳胶导尿管开发一种抗菌双网络水凝胶涂层，该涂层将银量子点（Ag QDs）掺入聚乙烯醇（PVA）-壳聚糖（CS）双网络水凝胶基质中。被称为PCA水凝胶涂层的PVA-CS-Ag QDs表现出优异的机械和物理化学性质，并能控制Ag QDs的释放。对PCA水凝胶涂层导尿管针对革兰氏阴性大肠杆菌（E. coli，ATCC25922）和革兰氏阳性金黄色葡萄球菌（S. aureus，ATCC29213）的抗菌性能进行了研究。水凝胶涂层中CS低聚物和Ag QDs的持续释放促成了协同抗菌和抗粘附作用。Ag释放速率的测量结果表明，即使在30天后，PCA水凝胶涂层导尿管中Ag QDs的浓度仍显著高于总Ag的有效抗菌浓度（0.1μg·L）。这些结果表明，PCA水凝胶涂层不仅能有效防止细菌附着，还具有长期抗菌活性，从而抑制生物膜形成。此外，PCA水凝胶涂层导尿管表现出优异的生物相容性和血液相容性。总体而言，这种具有卓越抗菌性能的新型PCA水凝胶涂层导尿管在降低CAUTIs发病率方面具有巨大潜力。
