Faculty of Medical School, University of Versailles-Saint-Quentin-en-Yvelines, Montigny-Le-Bretonneux, France.
Department of Nephrology, Dialysis, and Transplantation, Foch Hospital, Suresnes, France.
BMC Nephrol. 2024 Oct 18;25(1):363. doi: 10.1186/s12882-024-03788-4.
BK-polyomavirus (BKpyV) nephropathy (BKVN) is associated with end-stage kidney disease in kidney and non-kidney solid organ transplantation, with no curative treatment.
A 45-year-old woman with a past medical history of double lung transplantation subsequently developed end-stage kidney disease, of undetermined origin. One month after receiving a kidney transplant, a diagnosis of early BKVN was suspected, and in retrospect was a reasonable cause for the loss of her native kidneys. Minimisation of immunosuppression, achieved through extracorporeal photopheresis, allowed clearance of BKpyV and so prevented nephropathy. Both lung and kidney grafts had a satisfactory and stable function after one year of follow-up, with no rejection.
Extracorporeal photopheresis may have facilitated minimisation of immunosuppression and BKpyV clearance without lung allograft rejection.
BK 多瘤病毒（BKpyV）肾病（BKVN）与肾和非肾实体器官移植的终末期肾病有关，目前尚无治愈方法。
一名 45 岁女性，既往有双肺移植病史，后发生原因不明的终末期肾病。在接受肾移植后 1 个月，怀疑为早期 BKpyV 感染，回顾性分析认为这是导致其自身肾脏丧失的合理原因。通过体外光化学疗法（extracorporeal photopheresis）减少免疫抑制，使 BKpyV 清除，从而预防了肾病。在 1 年的随访中，肺和肾移植物的功能均令人满意且稳定，没有发生排斥反应。
体外光化学疗法可能有助于在不发生肺移植物排斥的情况下减少免疫抑制和 BKpyV 清除。
