Department of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
Department of Neurological Surgery, NewYork-Presbyterian Weill Cornell Medicine, New York, New York, USA.
World Neurosurg. 2024 Oct;190:564-572. doi: 10.1016/j.wneu.2024.06.143.
Within neurosurgery, it has always been important to individualize patient care. In recent years, however, technological advances have brought a new dimension to personalized care as developing methods, including next-generation sequencing, have enabled us to molecularly profile pathologies with increasing scale and resolution. In this review, the authors discuss the history and advances in precision medicine and neurosurgery, focusing both on neuro-oncology, as well as its extension to other neurosurgical subspecialties. They highlight the important roles of neurosurgeons in past work and future work, with the extension of tissue collection and precision medicine principles to additional sample types and disease indications.
在神经外科学中，一直以来，为患者提供个性化的医疗服务都至关重要。然而，近年来，技术的进步为个性化医疗带来了新的维度，包括下一代测序在内的各种新方法使我们能够以越来越大的规模和更高的分辨率对病理进行分子分析。在这篇综述中，作者讨论了精准医学和神经外科学的历史和进展，重点讨论了神经肿瘤学，以及其向其他神经外科学亚专业的扩展。他们强调了神经外科医生在过去和未来工作中的重要作用，包括将组织收集和精准医疗原则扩展到其他样本类型和疾病适应症。
