Department of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
Department of Neurological Surgery, NewYork-Presbyterian Weill Cornell Medicine, New York, New York, USA.
World Neurosurg. 2024 Oct;190:573-581. doi: 10.1016/j.wneu.2024.06.142.
Recent developments in technology have led to rapid advances in precision medicine, especially due to the rise of next-generation sequencing and molecular profiling. These technological advances have led to rapid advances in research, including increased tumor subtype resolution, new therapeutic agents, and mechanistic insights. Certain therapies have even been approved for molecular biomarkers across histopathological diagnoses; however, translation of research findings to the clinic still faces a number of challenges. In this review, the authors discuss several key challenges to the clinical integration of precision medicine, including the blood-brain barrier, both a lack and excess of molecular targets, and tumor heterogeneity/escape from therapy. They also highlight a few key efforts to address these challenges, including new frontiers in drug delivery, a rapidly expanding treatment repertoire, and improvements in active response monitoring. With continued improvements and developments, the authors anticipate that precision medicine will increasingly become the gold standard for clinical care.
最近技术的发展导致精准医学的快速进步，特别是由于下一代测序和分子谱分析的兴起。这些技术进步导致了研究的快速进展，包括增加肿瘤亚型分辨率、新的治疗药物和机制见解。某些治疗方法甚至已被批准用于基于分子标志物的病理诊断；然而，将研究结果转化为临床实践仍然面临许多挑战。在这篇综述中，作者讨论了精准医学临床整合的几个关键挑战，包括血脑屏障、分子靶点的缺乏和过量以及肿瘤异质性/治疗逃逸。他们还强调了一些解决这些挑战的关键努力，包括药物输送的新前沿、治疗方案的迅速扩展以及主动监测的改进。随着持续的改进和发展，作者预计精准医学将越来越成为临床护理的黄金标准。
