P4-ATPase 缺失对膜不对称性和疾病发展的影响。

Impacts of P4-ATPase Deletion on Membrane Asymmetry and Disease Development.

机构信息

School of Public Health, Kunming Medical University, Kunming, China.

出版信息

Cell Biochem Funct. 2024 Sep;42(7):e70004. doi: 10.1002/cbf.70004.

Abstract

Phospholipids exhibit an asymmetrical distribution on the cell membrane. P4-ATPases, type IV lipid flippases, are responsible for establishing and maintaining this phospholipid compositional asymmetry. The essential β subunit CDC50 (also known as TMEM30) assists in the transport and proper functioning of P4-ATPases. Deletion of P4-ATPases and its β subunit disrupts the membrane asymmetry, impacting the growth and development and leading to various diseases affecting the nervous, skeletal muscle, digestive, and hematopoietic systems. This review discusses the crucial roles of P4-ATPases and their β subunit in Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, and mammals, offering valuable insights for future research.

摘要

磷脂在细胞膜上表现出不对称分布。P4-ATP 酶，即第四型脂质翻转酶，负责建立和维持这种磷脂组成的不对称性。必需的β亚基 CDC50（也称为 TMEM30）协助 P4-ATP 酶的运输和正常功能。P4-ATP 酶及其β亚基的缺失破坏了膜的不对称性，影响了生长和发育，并导致影响神经、骨骼肌、消化和造血系统的各种疾病。本综述讨论了 P4-ATP 酶及其β亚基在酿酒酵母、拟南芥、秀丽隐杆线虫和哺乳动物中的关键作用，为未来的研究提供了有价值的见解。