Jiang Ying, Chen Xiaofeng, Li Shaoxing, Huang Chaolin, Cheng Xuehua
Department of Obstetrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Department of Gynecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Int J Gynaecol Obstet. 2025 Mar;168(3):1101-1108. doi: 10.1002/ijgo.15971. Epub 2024 Oct 19.
Early identification of women at risk of developing pre-eclampsia is beneficial as it allows for timely intervention strategies. This study aimed to evaluate the potential of serum Numb in the first trimester as a biomarker for early prediction of pre-eclampsia.
This prospective observational cohort study was carried out at a tertiary teaching hospital between January 2021 and December 2022. A total of 1024 women were recruited during their 8-13 weeks of pregnancy and were followed up until delivery. Serum Numb levels were measured during 8-13 weeks of gestation for all participants. At the same time, the participants' anthropometric, clinical, and laboratory data were collected. A logistic regression model was used to investigate the potential association between serum Numb levels and the risk of pre-eclampsia. Receiver operating characteristic curves (ROCs) and area under the curves (AUCs) were utilized to evaluate the predictive efficacy of serum Numb levels for pre-eclampsia in the first trimester.
Serum Numb levels were found to be significantly higher in pregnant women who developed pre-eclampsia compared to those who did not develop pre-eclampsia. Increased serum Numb levels were identified as an independent risk factor for pre-eclampsia, with an odds ratio (OR) of 3.27 (95% CI: 2.05-4.53) for the risk of pre-eclampsia. Numb levels showed a significant positive correlation with the risk of pre-eclampsia. Furthermore, Numb levels demonstrated a strong predictive efficacy for pre-eclampsia in the first trimester of pregnancy, with an AUC value of 0.86, a cutoff value of 48.73 ng/mL, a sensitivity of 79.24%, and a specificity of 75.73%.
Serum Numb in the first trimester of pregnancy can serve as a biomarker for the early prediction of pre-eclampsia. This provides a valuable approach in clinical practice to identify pregnant women in the first trimester of pregnancy, who are at a higher risk of developing pre-eclampsia.
早期识别有发生子痫前期风险的女性是有益的，因为这有助于采取及时的干预策略。本研究旨在评估孕早期血清Numb作为子痫前期早期预测生物标志物的潜力。
这项前瞻性观察队列研究于2021年1月至2022年12月在一家三级教学医院进行。共招募了1024名在孕8 - 13周的女性，并随访至分娩。所有参与者在妊娠8 - 13周时测量血清Numb水平。同时，收集参与者的人体测量、临床和实验室数据。采用逻辑回归模型研究血清Numb水平与子痫前期风险之间的潜在关联。利用受试者工作特征曲线（ROC）和曲线下面积（AUC）评估孕早期血清Numb水平对子痫前期的预测效能。
发现发生子痫前期的孕妇血清Numb水平显著高于未发生子痫前期的孕妇。血清Numb水平升高被确定为子痫前期的独立危险因素，子痫前期风险的比值比（OR）为3.27（95%CI：2.05 - 4.53）。Numb水平与子痫前期风险呈显著正相关。此外，Numb水平在孕早期对子痫前期具有较强的预测效能，AUC值为0.86，截断值为48.73 ng/mL，灵敏度为79.24%，特异度为75.73%。
孕早期血清Numb可作为子痫前期早期预测的生物标志物。这为临床实践中识别孕早期发生子痫前期风险较高的孕妇提供了一种有价值的方法。
