小鼠肝脏和肾脏中环氧水解酶的亚细胞定位。
Subcellular localization of epoxide hydrolase in mouse liver and kidney.
作者信息
Patel B N, Mackness M I, Nwosu V, Connock M J
出版信息
Biochem Pharmacol. 1986 Jan 15;35(2):231-5. doi: 10.1016/0006-2952(86)90519-8.
PMID:3942597
Abstract
The subcellular distribution of epoxide hydrolase activity towards TSO and HEOM in mouse liver and kidney was investigated using zonal rotor centrifugation. Epoxide hydrolase activity towards TSO was found predominantly in the soluble fraction with peroxisomes accounting for activity in the particulate fractions. Renal particulate activity towards HEOM was found predominantly in the microsomes.
摘要
利用区带转子离心法研究了小鼠肝脏和肾脏中对反式环氧十八碳三烯酸（TSO）和六氯环氧十八碳三烯酸（HEOM）的环氧水解酶活性的亚细胞分布。发现对TSO的环氧水解酶活性主要存在于可溶性部分，而过氧化物酶体在颗粒部分具有活性。发现肾脏中对HEOM的颗粒活性主要存在于微粒体中。
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