小鼠肝脏分离过氧化物酶体中的环氧水解酶活性
Epoxide hydrolase activity in isolated peroxisomes of mouse liver.
作者信息
Waechter F, Bentley P, Bieri F, Stäubli W, Völkl A, Fahimi H D
出版信息
FEBS Lett. 1983 Jul 25;158(2):225-8. doi: 10.1016/0014-5793(83)80583-3.
PMID:6873276
Abstract
Using trans-stilbene oxide as substrate, the subcellular distribution of epoxide hydrolase was investigated in livers from DBA/2 mice. The highest specific activities were found in cytosolic and light mitochondrial fractions. Isopycnic subfractionation of the light mitochondrial fraction showed that the organelle-bound trans-stilbene oxide hydrolase is localized in peroxisomes.
摘要
以反式氧化芪为底物，研究了DBA/2小鼠肝脏中环氧化物水解酶的亚细胞分布。在胞质和轻度线粒体组分中发现了最高的比活性。对轻度线粒体组分进行等密度亚分级分离表明，与细胞器结合的反式氧化芪水解酶定位于过氧化物酶体中。
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