Sadeghi Elham, Valsecchi Nicola, Rahmanipour Elham, Ejlalidiz Mahsa, Hasan Nasiq, Vupparaboina Kiran Kumar, Ibrahim Mohammed Nasar, Rasheed Mohammed Abdul, Baek Jiwon, Iannetta Danilo, Chhablani Jay
University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Surv Ophthalmol. 2025 Mar-Apr;70(2):167-183. doi: 10.1016/j.survophthal.2024.10.004. Epub 2024 Oct 18.
Age-related macular degeneration (AMD) is the leading cause of central visual impairment in the elderly. The exact pathophysiological mechanisms for AMD remain uncertain. Several studies suggest that choroidal abnormalities and alterations are critical in AMD progression. The transition from manual to automated segmentation and binarization techniques has resulted in accurate and precise measurements of different choroidal parameters. These qualitative and quantitative parameters, known as choroidal imaging biomarkers, have advanced from basic vertical subfoveal choroidal thickness to more intricate 3-dimensional choroidal reconstruction methods in the last decade. Therefore, a comprehensive evaluation of choroidal metrics may investigate valuable insights into AMD, potentially guiding the future development of customized therapeutic strategies and personalized patient care in AMD management. We describe the role of different choroidal biomarkers in evaluating patients with AMD and their contribution to management.
年龄相关性黄斑变性（AMD）是老年人中心视力损害的主要原因。AMD的确切病理生理机制尚不确定。多项研究表明，脉络膜异常和改变在AMD进展中至关重要。从手动分割和二值化技术向自动分割和二值化技术的转变，使得对不同脉络膜参数的测量更加准确和精确。在过去十年中，这些被称为脉络膜成像生物标志物的定性和定量参数，已经从基本的垂直黄斑中心凹下脉络膜厚度发展到更复杂的三维脉络膜重建方法。因此，对脉络膜指标进行全面评估可能会为AMD研究提供有价值的见解，有可能为AMD管理中定制治疗策略和个性化患者护理的未来发展提供指导。我们描述了不同脉络膜生物标志物在评估AMD患者中的作用及其对管理的贡献。
