视网膜脉络膜厚度及血管指标与玻璃膜疣体积的相关性作为年龄相关性黄斑变性严重程度的标志物

Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.

作者信息

Sadeghi Elham, Schulman Anne, Vupparaboina Sharat Chandra, Singh Sumit Randhir, Hasan Nasiq, Bollepalli Sandeep Chandra, Vupparaboina Kiran Kumar, Sahel Jose Alain, Eller Andrew W, Chhablani Jay

机构信息

University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

Wichita State University, School of Computing, Wichita, KS, USA.

出版信息

Eye (Lond). 2025 May 15. doi: 10.1038/s41433-025-03847-6.

DOI:10.1038/s41433-025-03847-6

PMID:40374933

Abstract

PURPOSE

To assess retinal vascular perfusion and choroidal vascularity biomarkers correlated with drusen volume and severity of age-related macular degeneration (AMD).

METHODS

Patients underwent swept-source optical coherence tomography angiography (SS-OCTA) (PlexElite-9000). Eyes with geographic atrophy or neovascular AMD were excluded. Retinal thickness, retinal perfusion including superficial (SCP) and deep capillary plexuses (DCP), foveal avascular zone (FAZ), drusen volume, choroidal thickness (ChT) and choroidal vascularity index (CVI) were assessed through the Advanced Research and Innovation Network. Linear mixed model and Spearman test were used for statistical analysis.

RESULTS

We assessed 81 eyes from 57 subjects (34 early-stage, 47 intermediate-stage AMD). The mean age was 74.95 ± 8.79 years. The mean LogMar visual acuity (VA) was 0.16 ± 0.18 (early-stage: 0.12 ± 0.17, intermediate-stage: 0.19 ± 0.18, P = 0.122). Between early and intermediate AMD, no significant differences were seen in SCP and DCP vascular perfusion (P = 0.368, 0.859, respectively), FAZ (p = 0.836) and retinal thickness within the 6-mm area (P = 0.680). Drusen volume showed a significant difference (early-stage: 0.0706 ± 0.1272, intermediate-stage: 0.2102 ± 0.2211mm, P < 0.01). Intermediate-stage AMD had significantly lower mean ChT (266.40 ± 115.55 vs. 204.97 ± 70.69 µm, P = 0.038) and CVI (0.605 ± 0.021 vs. 0.591 ± 0.015, P = 0.004) within the 5-mm area. Drusen volume was negatively correlated with ChT (r = -0.198, P = 0.017) and CVI (r = -0.209, P = 0.029). No significant correlation was found between drusen volume and VA (r = 0.051, P = 0.143), retinal thickness (-0.03, P = 0.393), FAZ (r = -0.023, P = 0.150), SCP (r = -0.011, P = 0.307), and DCP (r = -0.022, P = 0.190).

CONCLUSION

Drusen volume, a key AMD severity marker, correlates more strongly with choroidal parameters like ChT and CVI than retinal thickness and perfusion. It may serve as a biomarker for dry AMD severity, with choroidal biomarkers showing earlier disease changes.

摘要

目的

评估与玻璃膜疣体积及年龄相关性黄斑变性（AMD）严重程度相关的视网膜血管灌注和脉络膜血管生成生物标志物。

方法

患者接受扫频光学相干断层扫描血管造影（SS-OCTA）（PlexElite-9000）检查。排除患有地图样萎缩或新生血管性AMD的眼睛。通过高级研究与创新网络评估视网膜厚度、视网膜灌注，包括浅层（SCP）和深层毛细血管丛（DCP）、黄斑无血管区（FAZ）、玻璃膜疣体积、脉络膜厚度（ChT）和脉络膜血管生成指数（CVI）。采用线性混合模型和Spearman检验进行统计分析。

结果

我们评估了57名受试者的81只眼睛（34只早期、47只中期AMD）。平均年龄为74.95±8.79岁。平均LogMar视力（VA）为0.16±0.18（早期：0.12±0.17，中期：0.19±0.18，P = 0.122）。在早期和中期AMD之间，SCP和DCP血管灌注（分别为P = 0.368、0.859）、FAZ（P = 0.836）以及6毫米区域内的视网膜厚度（P = 0.680）均无显著差异。玻璃膜疣体积存在显著差异（早期：0.0706±0.1272，中期：0.2102±0.2211mm，P < 0.01）。中期AMD在5毫米区域内的平均ChT（266.40±115.55对204.97±70.69µm，P = 0.038）和CVI（0.605±0.021对0.591±0.015，P = 0.004）显著更低。玻璃膜疣体积与ChT（r = -0.198，P = 0.017）和CVI（r = -0.209，P = 0.029）呈负相关。玻璃膜疣体积与VA（r = 0.051，P = 0.143）、视网膜厚度（-0.03，P = 0.393）、FAZ（r = -0.023，P = 0.150）、SCP（r = -0.011，P = 0.307）和DCP（r = -0.022，P = 0.190）之间未发现显著相关性。