Faculty of Data Science, Musashino University, 3-3-3 Ariake Koto-ku, Tokyo, 135-8181, Japan.
Chem Biol Interact. 2024 Dec 1;404:111282. doi: 10.1016/j.cbi.2024.111282. Epub 2024 Oct 18.
This review examines how various medications can trigger inflammation throughout the body. It explores causes, ranging from common pain relievers like NSAIDs to chemotherapy drugs. The review also highlights potential treatments, including established medications and promising new therapies. Physicians and patients can work together to reduce this risk by understanding these causes and implementing preventive measures, such as monitoring for side effects and using alternative medications when possible. Drug-induced inflammation can be categorized into four types based on the immune response involved. Symptoms vary by type and affected organ. Common symptoms include fever, malaise, joint pain, rash, and swelling. Diagnosis involves blood tests, imaging, and biopsies. Treatment primarily involves discontinuing the suspected drug and providing supportive care. The development of new drugs and therapies has made diagnosis challenging. However, recent advances in biomarkers and genetic risk assessment techniques are improving diagnosis and risk assessment of drug-induced liver injury. Preventive measures for drug-induced inflammation include monitoring for side effects, using alternative medications, developing new drug delivery methods, exploring new anti-inflammatory drugs, being aware of rare side effects, and understanding the underlying mechanisms.
这篇综述探讨了各种药物如何在全身引发炎症。它探讨了从常见的止痛药（如 NSAIDs）到化疗药物等各种原因。综述还强调了潜在的治疗方法，包括已确立的药物和有前途的新疗法。医生和患者可以通过了解这些原因并采取预防措施，例如监测副作用和在可能的情况下使用替代药物，共同降低这种风险。根据涉及的免疫反应，药物引起的炎症可分为四种类型。症状因类型和受影响的器官而异。常见症状包括发热、不适、关节痛、皮疹和肿胀。诊断包括血液检查、影像学检查和活组织检查。治疗主要包括停止可疑药物和提供支持性护理。新药物和疗法的开发使得诊断变得具有挑战性。然而，生物标志物和遗传风险评估技术的最新进展正在改善药物性肝损伤的诊断和风险评估。药物引起的炎症的预防措施包括监测副作用、使用替代药物、开发新的药物输送方法、探索新的抗炎药物、注意罕见的副作用以及了解潜在的机制。
