Richards D G, McPherson J J, Evans K T, Rosen M
Br J Anaesth. 1986 Jan;58(1):41-4. doi: 10.1093/bja/58.1.41.
Thirty-three patients received either 10 ml (group A) or 50 ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an important minority (16.7% (group A) and 20% (group B], absorption was delayed to beyond 60 min. There was a wide scatter of plasma diazepam concentrations in both groups. Dysphagia during swallowing did not appear to delay absorption.
33名患者在仰卧位时接受了10毫升（A组）或50毫升（B组）含有地西泮片的水作为术前用药。测量了血浆地西泮浓度，血浆浓度达到峰值的延迟被视为吸收延迟和食管滞留的指标。两组之间没有差异，尽管在一小部分重要患者中（A组为16.7%，B组为20%），吸收延迟至60分钟以上。两组的血浆地西泮浓度分布都很分散。吞咽时的吞咽困难似乎并未延迟吸收。
