Rutgers Institute for Health, Health Care Policy and Aging Research, Rutgers University, 112 Paterson Street, New Brunswick, NJ, 08901, USA.
Division of Cardiovascular Diseases and Hypertension, Rutgers Biomedical and Health Sciences, Robert Wood Johnson Medical School, 125 Paterson St, New Brunswick, NJ, USA.
Hum Genomics. 2024 Oct 19;18(1):116. doi: 10.1186/s40246-024-00685-7.
Periodontitis is a highly prevalent inflammatory illness that leads to the destruction of tooth supporting tissue structures and has been associated with an increased risk of cardiovascular disease (CVD). Precision medicine, an emerging branch of medical treatment, aims can further improve current traditional treatment by personalizing care based on one's environment, genetic makeup, and lifestyle. Genomic databases have paved the way for precision medicine by elucidating the pathophysiology of complex, heritable diseases. Therefore, the investigation of novel periodontitis-linked genes associated with CVD will enhance our understanding of their linkage and related biochemical pathways for targeted therapies. In this article, we highlight possible mechanisms of actions connecting PD and CVD. Furthermore, we delve deeper into certain heritable inflammatory-associated pathways linking the two. The goal is to gather, compare, and assess high-quality scientific literature alongside genomic datasets that seek to establish a link between periodontitis and CVD. The scope is focused on the most up to date and authentic literature published within the last 10 years, indexed and available from PubMed Central, that analyzes periodontitis-associated genes linked to CVD. Based on the comparative analysis criteria, fifty-one genes associated with both periodontitis and CVD were identified and reported. The prevalence of genes associated with both CVD and periodontitis warrants investigation to assess the validity of a potential linkage between the pathophysiology of both diseases.
牙周炎是一种高发的炎症性疾病，会导致牙齿支持组织结构的破坏，并与心血管疾病（CVD）风险增加相关。精准医学是医学治疗的一个新兴分支，旨在通过根据个人的环境、基因构成和生活方式来个性化护理，进一步改进当前的传统治疗方法。基因组数据库通过阐明复杂的遗传性疾病的病理生理学，为精准医学铺平了道路。因此，研究与 CVD 相关的新型牙周炎相关基因将增强我们对其关联和相关生化途径的理解，以实现靶向治疗。在本文中，我们强调了连接 PD 和 CVD 的可能作用机制。此外，我们还深入探讨了将两者联系起来的某些遗传性炎症相关途径。目标是收集、比较和评估基因组数据集以及高质量的科学文献，以建立牙周炎和 CVD 之间的联系。范围集中在过去 10 年内发表的最新和最真实的文献上，这些文献来自 PubMed Central 索引，并分析了与 CVD 相关的牙周炎相关基因。根据比较分析标准，确定并报告了 51 个与牙周炎和 CVD 均相关的基因。与 CVD 和牙周炎均相关的基因的流行程度值得研究，以评估这两种疾病的病理生理学之间存在潜在联系的有效性。
