Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell Rep. 2024 Nov 26;43(11):114871. doi: 10.1016/j.celrep.2024.114871. Epub 2024 Oct 19.
Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our understanding of the circuits underlying the non-associative impacts of stress, such as heightened stress sensitivity and anxiety-related behavior, is limited. Here, we demonstrate that the ventral hippocampus (vHC) and basolateral amygdala (BLA) support distinct non-associative behavioral changes following stress. Inhibiting stress-induced protein synthesis in the BLA blocked subsequent increases in stress sensitivity but not anxiety-related behaviors. Conversely, inhibiting stress-induced protein synthesis in the vHC blocked subsequent increases in anxiety-related behavior but not stress sensitivity. Inhibiting neuronal activity in the BLA and vHC during the assessment of stress sensitivity or anxiety-related behavior recapitulated these structures' dissociable contributions to defensive behavior. Lastly, blocking the associative memory of a stressor had no impact on stress-induced changes in anxiety-related behavior. These findings highlight that multiple memory systems support the long-lasting effects of stress.
压力会对心理健康产生深远的影响。虽然人们对支持应激事件关联记忆的神经回路有了很多了解，但我们对压力非联想影响（如应激敏感性增强和焦虑相关行为）背后的回路的理解还很有限。在这里，我们证明腹侧海马体（vHC）和基底外侧杏仁核（BLA）在应激后支持不同的非联想行为变化。抑制 BLA 中的应激诱导蛋白合成会阻止随后的应激敏感性增加，但不会阻止焦虑相关行为。相反，抑制 vHC 中的应激诱导蛋白合成会阻止随后的焦虑相关行为增加，但不会阻止应激敏感性增加。在评估应激敏感性或焦虑相关行为时抑制 BLA 和 vHC 的神经元活动，再现了这些结构对防御行为的可分离贡献。最后，阻断应激源的关联记忆对焦虑相关行为的应激诱导变化没有影响。这些发现强调了多个记忆系统支持压力的持久影响。
