Zaets T L, Sologub V K, Maĭzelis M Ia, Zabludovskiĭ A L, Shikhov S N
Biull Eksp Biol Med. 1986 Jan;101(1):10-1.
The dynamics of met-and leu-enkephalin content in the brain cortex and hypothalamus of rats with severe burn shock caused by 50% burns by boiling water were studied. A tendency towards burn-induced growth in leu-enkephalin hypothalamus level was observed, with the content of met-and leu-enkephalins in the hypothalamus significantly increasing 30 min later. Met-enkephalin content in the brain cortex also rises. 2 hours later the changes are less pronounced, with met-enkephalin hypothalamus level remaining elevated. The adaptive nature of changes, mobilization of endogenous anti-pain defensive mechanisms in severe burn shock and the role of hypothalamus structures in this process are suggested.
研究了50%沸水烫伤致大鼠严重烧伤休克时大脑皮层和下丘脑中甲硫氨酸脑啡肽和亮氨酸脑啡肽含量的动态变化。观察到下丘脑亮氨酸脑啡肽水平有烧伤诱导升高的趋势，30分钟后下丘脑甲硫氨酸脑啡肽和亮氨酸脑啡肽含量显著增加。大脑皮层中甲硫氨酸脑啡肽含量也升高。2小时后变化不太明显，下丘脑甲硫氨酸脑啡肽水平仍升高。提示了这些变化的适应性本质、严重烧伤休克时内源性抗痛防御机制的动员以及下丘脑结构在此过程中的作用。
