Ruzuddinov S R, Rys-Uly M
Biull Eksp Biol Med. 1986 Jan;101(1):109-12.
The experiments on rats kept for 1, 2, 3 and 4 months in phosphorous-producing workshops revealed the influence of elementary phosphorous and its nonorganic derivatives on the mouth mucosa tissues. At the early stages of the experiments the above agents caused the increase in the number of the epithelial layer cell elements, and strengthening of the keratosis process, leading to the development of hyperkeratosis. By the end of the experiment the development of dystrophic and atrophic processes in the epithelium were observed, which sometimes caused thinning of the epithelial layer. The connective tissue of submucous basis was characterized by microcirculation disorders and dystrophic disturbances of blood vessel walls becoming more pronounced by the end of the experiment.
对在产磷车间饲养1、2、3和4个月的大鼠进行的实验揭示了单质磷及其无机衍生物对口腔黏膜组织的影响。在实验早期，上述物质导致上皮层细胞数量增加，角化过程增强，进而发展为角化过度。到实验结束时，观察到上皮出现营养不良和萎缩性变化，有时导致上皮层变薄。黏膜下层的结缔组织表现为微循环障碍，血管壁的营养不良性病变在实验结束时更加明显。
