[Genetic and seasonal characteristics of the effect of stress on pain sensitivity in mice].

The role of genetic and seasonal factors in stress-induced changes of pain sensitivity, evaluated by latency in hot plate test was studied. Significant interstrain differences in restriction effect on pain sensitivity was established. Analgesia, hyperalgesia or lack of influence on pain sensitivity in mice of different strains was observed in response to emotional stress. Interstrain differences in seasonal variance of stress-induced changes in pain sensitivity were shown. It is suggested that changes in pain sensitivity of mice after restriction are season-dependent and controlled by hereditary mechanisms.