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[应激状态下遗传与环境因素对小鼠脑内色氨酸羟化酶活性的交互作用]

[Interaction of genetic and environmental components in the determination of tryptophan hydroxylase activity in the mouse brain in stress].

作者信息

Kulikov A V, Koriakina L A, Popova N K

出版信息

Genetika. 1985 Oct;21(10):1680-4.

PMID:4065558
Abstract

The interaction between genetic and environmental components of phenotype variety in the response to cold and emotional stress of the brain serotonin system was studied in 11 inbred strains of mice. It was shown that the variety in the degree of tryptophan hydroxylase activity's changes under stress are mainly due to the genotypic differences. The presence of different genotypic systems controlling the activity of tryptophan hydroxylase under basal conditions and under stress was revealed. Differences in hereditary mechanisms determining the tryptophan hydroxylase reactions to different kinds of stress were noted.

摘要

在11个近交系小鼠中研究了大脑5-羟色胺系统对寒冷和情绪应激反应中表型多样性的遗传和环境成分之间的相互作用。结果表明,应激状态下色氨酸羟化酶活性变化程度的差异主要归因于基因型差异。揭示了在基础条件和应激状态下控制色氨酸羟化酶活性的不同基因型系统的存在。注意到决定色氨酸羟化酶对不同类型应激反应的遗传机制存在差异。

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