Xu Ting, Wang Shuang, Ma Tingting, Dong Yawen, Ashby Charles R, Hao Ge-Fei
School of Pharmaceutical Sciences, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang 550025, China.
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China.
Drug Discov Today. 2024 Dec;29(12):104215. doi: 10.1016/j.drudis.2024.104215. Epub 2024 Oct 18.
Accurately identifying biological targets is crucial for advancing treatment options. Essential genes, vital for cell or organism survival, hold promise as potential drug targets in disease treatment. Although many studies have sought to identify essential genes as therapeutic targets in medicine and bioinformatics, systematic reviews on their relationship with drug targets are relatively rare. This work presents a comprehensive analysis to aid in identifying essential genes as potential targets for drug discovery, encompassing their relevance, identification methods, successful case studies, and challenges. This work will facilitate the identification of essential genes as therapeutic targets, thereby boosting new drug development.
准确识别生物学靶点对于推进治疗方案至关重要。对细胞或生物体生存至关重要的必需基因有望成为疾病治疗中的潜在药物靶点。尽管许多研究试图在医学和生物信息学中将必需基因鉴定为治疗靶点，但关于它们与药物靶点关系的系统综述相对较少。这项工作进行了全面分析，以帮助将必需基因鉴定为药物发现的潜在靶点，包括它们的相关性、鉴定方法、成功案例研究和挑战。这项工作将有助于将必需基因鉴定为治疗靶点，从而推动新药开发。
