Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chin J Nat Med. 2024 Oct;22(10):887-899. doi: 10.1016/S1875-5364(24)60693-X.
Toosendanin (TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including proliferation inhibition, apoptosis induction, migration suppression, and angiogenesis inhibition. However, TSN's toxicity, particularly its hepatotoxicity, significantly limits its therapeutic application. This review explored the dual nature of TSN, evaluating both its anticancer potential and toxicological risks, emphasizing the importance of balancing these aspects in therapeutic applications. Furthermore, we investigated the incorporation of TSN into novel therapeutic strategies, such as Proteolysis-targeting chimeras (PROTAC) technology and nanotechnology-based drug delivery systems (DDS), which enhance treatment efficacy while mitigating toxicity in normal tissues.
川楝素（TSN）是从川楝和苦楝中提取的四环三萜类化合物，在癌症治疗方面具有广泛的应用前景。虽然它曾被用作农药，但最近的研究表明，它在治疗多种类型的癌症方面具有潜在的治疗价值。TSN 通过抑制增殖、诱导凋亡、抑制迁移和抑制血管生成等机制发挥抗癌作用。然而，TSN 的毒性，特别是其肝毒性，极大地限制了其治疗应用。本综述探讨了 TSN 的双重性质，评估了其抗癌潜力和毒理学风险，强调了在治疗应用中平衡这两方面的重要性。此外，我们研究了将 TSN 纳入新型治疗策略，如蛋白水解靶向嵌合体（PROTAC）技术和基于纳米技术的药物传递系统（DDS），这些策略可以提高治疗效果，同时减轻正常组织的毒性。
