Li A L, Zhang J L, Luo W T, Liu L, Sun B Q
Department of Clinical Laboratory, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Oct 6;58(10):1631-1639. doi: 10.3760/cma.j.cn112150-20240731-00611.
Vegetable and fruit allergies are common types of food allergies worldwide, most of them are triggered by primary sensitization to pollen. Most allergens in vegetables and fruits belong to a few cross-reactive proteins such as PR-10 proteins, profilins, and nsLTPs. The presence of these allergens in various plants can lead to widespread cross-reactive allergic responses. Component-resolved diagnostics (CRD) can improve diagnostic accuracy by precisely identifying specific allergenic proteins, aiding physicians in making more accurate treatment and management decisions, and reducing unnecessary food avoidance. This article, based on the "Molecular Allergology User's Guide 2.0 (MAUG 2.0)" issued by the European Academy of Allergy and Clinical Immunology (EAACI), analyzes the primary mechanisms, relevant allergens, and diagnostic and clinical management strategies for vegetable and fruit allergies. By detailing and analyzing these allergenic components, this article may help the healthcare professionals to deep the understandings of vegetable and fruit allergies, offer new perspectives and practical guideline for the research and treatment of these allergies, and promot the development of precise diagnostics and personalized treatment strategies.
蔬菜和水果过敏是全球常见的食物过敏类型，其中大多数是由对花粉的初次致敏引发的。蔬菜和水果中的大多数过敏原属于少数几种交叉反应蛋白，如PR-10蛋白、肌动蛋白结合蛋白和非特异性脂质转移蛋白。这些过敏原在各种植物中的存在会导致广泛的交叉反应性过敏反应。组分分辨诊断（CRD）可以通过精确识别特定的致敏蛋白来提高诊断准确性，帮助医生做出更准确的治疗和管理决策，并减少不必要的食物回避。本文基于欧洲变态反应和临床免疫学会（EAACI）发布的《分子变态反应学用户指南2.0（MAUG 2.0）》，分析了蔬菜和水果过敏的主要机制、相关过敏原以及诊断和临床管理策略。通过详细阐述和分析这些致敏成分，本文可能有助于医疗保健专业人员加深对蔬菜和水果过敏的理解，为这些过敏的研究和治疗提供新的视角和实用指南，并促进精确诊断和个性化治疗策略的发展。
