Trull A K, Eastmond C J, Panayi G S, Reid T M
Br J Rheumatol. 1986 Feb;25(1):13-9. doi: 10.1093/rheumatology/25.1.13.
Serial measurements of serum and secretory antibodies to Salmonella typhimurium were made by ELISA in eight patients with suspected reactive arthritis identified after a large outbreak of Salmonella gastroenteritis. All three patients from whom Salmonella had been isolated developed significant serum IgG, IgA and IgM antibody responses. Only one of the three possessed HLA-B27. A further three patients, two with HLA-B27, had raised antibodies, although none had experienced gastroenteritis. Salmonella infection was not confirmed in the remaining two patients. The three B27-negative patients with confirmed reactive arthritis had HLA-B locus antigens which serologically cross-react with B27. One of six patients with confirmed reactive arthritis was under the age of 25 years whereas 256 of 418 (61%) patients with uncomplicated enteritis were under this age. The development of reactive arthritis may follow subclinical Salmonella infection and is influenced by genetic and age-related factors.
在一次大规模鼠伤寒沙门氏菌肠胃炎暴发后确诊的8例疑似反应性关节炎患者中，采用酶联免疫吸附测定法（ELISA）对血清及分泌型抗鼠伤寒沙门氏菌抗体进行了连续检测。所有3例分离出沙门氏菌的患者均产生了显著的血清IgG、IgA和IgM抗体反应。这3例患者中只有1例携带HLA - B27。另外3例患者，其中2例携带HLA - B27，抗体水平升高，尽管他们都没有患肠胃炎。其余2例患者未确诊有沙门氏菌感染。3例确诊反应性关节炎的B27阴性患者具有与B27发生血清学交叉反应的HLA - B位点抗原。6例确诊反应性关节炎的患者中有1例年龄在25岁以下，而418例（61%）无并发症肠炎患者中有256例年龄在这个年龄段以下。反应性关节炎的发生可能继发于亚临床沙门氏菌感染，并受遗传和年龄相关因素影响。
