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曲妥珠单抗延迟性心脏毒性导致严重左心室功能障碍。

Delayed Trastuzumab-induced Cardiotoxicity Leading to Severe Left Ventricular Dysfunction.

作者信息

Misumi Ikuo, Nishimura Reiki, Nakamura Shota, Sato Koji, Dekita Miwa, Usuku Hiroki, Tsujita Kenichi

机构信息

Department of Cardiology, Ueki Hospital, Japan.

Department of Surgery, Kumamoto Brest and Gastrointestinal Surgical Hospital, Japan.

出版信息

Intern Med. 2025 Jun 15;64(12):1849-1857. doi: 10.2169/internalmedicine.4144-24. Epub 2024 Oct 18.

DOI:10.2169/internalmedicine.4144-24
PMID:39428535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12241786/
Abstract

An 81-year-old woman presented to our hospital with dyspnea. She had been treated with trastuzumab for nine years. Chest radiography revealed pleural effusion. Transthoracic echocardiography revealed dyskinesis of the interventricular septum (IVS). Cardiac magnetic resonance imaging revealed increased native T1 values at the IVS and apex, indicating myocardial edema or fibrosis in these areas. A transthoracic echocardiogram after half a year revealed an increase in left ventricular ejection fraction from 25% to 48%. Serial transthoracic echocardiography and cardiac magnetic resonance imaging were useful for evaluating the cardiac structure and function in the present case of delayed trastuzumab-induced myocardial injury.

摘要

一名81岁女性因呼吸困难前来我院就诊。她接受曲妥珠单抗治疗已九年。胸部X线检查显示胸腔积液。经胸超声心动图显示室间隔运动障碍。心脏磁共振成像显示室间隔和心尖处的固有T1值升高，提示这些区域存在心肌水肿或纤维化。半年后的经胸超声心动图显示左心室射血分数从25%增加到48%。在本例曲妥珠单抗所致延迟性心肌损伤中，系列经胸超声心动图和心脏磁共振成像对于评估心脏结构和功能很有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/bb5e42167a5d/1349-7235-64-12-1849-g015.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/69ee8b570fde/1349-7235-64-12-1849-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/79049a9c233e/1349-7235-64-12-1849-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/bb5e42167a5d/1349-7235-64-12-1849-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/77e9eec71807/1349-7235-64-12-1849-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/72a759633af9/1349-7235-64-12-1849-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/fbaa03d9ae39/1349-7235-64-12-1849-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/f906d91c9796/1349-7235-64-12-1849-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/1d93a4726aa6/1349-7235-64-12-1849-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/59daf46f5f64/1349-7235-64-12-1849-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/a66966638f09/1349-7235-64-12-1849-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/2b73794b079e/1349-7235-64-12-1849-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/efefb089e581/1349-7235-64-12-1849-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/fcffda1f875b/1349-7235-64-12-1849-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/855eeb11fbcc/1349-7235-64-12-1849-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/69ee8b570fde/1349-7235-64-12-1849-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ac/12241786/bb5e42167a5d/1349-7235-64-12-1849-g015.jpg

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