Ma Yingjie, Yu Xinru, Liu Yi Fan, Song Bihan, Sun Zhengao, Zhao Shengtian
The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
School of PharmacyJinan, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Andrology. 2024 Oct 21. doi: 10.1111/andr.13772.
This paper investigates the complex relationship between the immune system and male reproductive processes, emphasizing how chronic inflammation can adversely affect male reproductive health. The immune system plays a dual role; it protects and regulates reproductive organs and spermatogenesis while maintaining reproductive health through immune privilege in the testes and the activities of various immune cells and cytokines. However, when chronic inflammation persists or intensifies, it can disrupt this balance, leading to immune attacks on reproductive tissues and resulting in infertility.This study provides a detailed analysis of how chronic inflammation can impair sperm production, sperm quality, and the secretion of gonadal hormones both directly and indirectly. It also delves into the critical roles of testicular immune privilege, various immune cells, and cytokines in sustaining reproductive health and examines the impacts of infections, autoimmune diseases, and environmental factors on male fertility.
本文研究了免疫系统与男性生殖过程之间的复杂关系，着重探讨了慢性炎症如何对男性生殖健康产生不利影响。免疫系统发挥着双重作用；它通过睾丸中的免疫豁免以及各种免疫细胞和细胞因子的活动来保护和调节生殖器官及精子发生，同时维持生殖健康。然而，当慢性炎症持续或加剧时，它会破坏这种平衡，导致对生殖组织的免疫攻击并造成不育。本研究详细分析了慢性炎症如何直接和间接损害精子生成、精子质量以及性腺激素的分泌。它还深入探讨了睾丸免疫豁免、各种免疫细胞和细胞因子在维持生殖健康中的关键作用，并研究了感染、自身免疫性疾病和环境因素对男性生育能力的影响。
