Potiris Anastasios, Moustakli Efthalia, Trismpioti Eleni, Drakaki Eirini, Mavrogianni Despoina, Matsas Alkis, Zikopoulos Athanasios, Sfakianakis Antonios, Tsakiridis Ioannis, Dagklis Themistoklis, Zachariou Athanasios, Christopoulos Panagiotis, Domali Ekaterini, Drakakis Peter, Stavros Sofoklis
Third Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
Metabolites. 2025 Apr 11;15(4):267. doi: 10.3390/metabo15040267.
BACKGROUND/OBJECTIVES: Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility and fertilization capability. It accomplishes this through damaging sperm DNA, oxidizing proteins, and triggering lipid peroxidation. These effects occur due to an imbalance between reactive oxygen species (ROS) and antioxidant defenses.
This review aims to evaluate the impact of oxidative stress and inflammation on male infertility by assessing recent literature.
Pro-inflammatory cytokines, like TNF-α and IL-6, interfere with spermatogenesis and promote oxidative damage. Additionally, infections caused by pathogens like and Chlamydia trachomatis alter the reproductive microenvironment, leading to sperm dysfunction and inflammation.
Early detection and targeted treatment are essential due to the intricate interactions among these elements. Microbiota-modulating techniques, antimicrobial therapies, anti-inflammatory drugs, and antioxidants are therapeutic approaches that may help reduce oxidative damage and enhance male fertility.
背景/目的：炎症、感染和氧化应激（OS）均对男性不育产生影响，男性不育是一种复杂、多方面的疾病。氧化应激会影响精子活力和受精能力。它通过损伤精子DNA、氧化蛋白质以及引发脂质过氧化来实现这一点。这些影响是由于活性氧（ROS）与抗氧化防御之间的失衡所致。
本综述旨在通过评估近期文献来评价氧化应激和炎症对男性不育的影响。
促炎细胞因子，如肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6），会干扰精子发生并促进氧化损伤。此外，由淋病奈瑟菌和沙眼衣原体等病原体引起的感染会改变生殖微环境，导致精子功能障碍和炎症。
由于这些因素之间存在复杂的相互作用，早期检测和靶向治疗至关重要。调节微生物群技术、抗菌疗法、抗炎药物和抗氧化剂是可能有助于减少氧化损伤并提高男性生育能力的治疗方法。
