Pascual Laura M H, Devy Jérôme, Colin Marius, Chazée Lise, Guillaneuf Alexandra, Marin Béatrice, Plantier-Royon Richard, Gatard Sylvain
Université de Reims Champagne-Ardenne, CNRS, ICMR, Reims, 51687, Reims Cedex 2, France.
Université de Reims Champagne-Ardenne, CNRS, MEDyC, Reims, France.
ChemMedChem. 2025 Feb 1;20(3):e202400565. doi: 10.1002/cmdc.202400565. Epub 2024 Nov 21.
A series of xylose-based ligands was obtained using a convenient approach, in a few steps from D-xylose. The complexation properties of these ligands towards Au cations have been studied through different methods (multinuclear NMR, mass spectrometry, elemental analysis). The biological properties (antibacterial and anti-tumoral) of all the isolated xyloside Au(III) complexes were investigated in vitro. The xyloside Au(III) complexes gave the highest activities against E. coli (vs P. aeruginosa, S. aureus and S. epidermidis). The study also revealed that the nature of the sugar may play an important role in determining the selectivity of the antibacterial effect. Preliminary anti-tumoral evaluations showed that one complex containing a polyamine chain, exhibited interesting anti-proliferative activities on breast tumor cell lines MDA-MB-231 and BT-20. The anti-migratory effect of this complex also showed an average 35 % reduction in cell migration on the same two cancer cell lines.
通过一种简便的方法，以D-木糖为原料，经过几步反应得到了一系列基于木糖的配体。通过不同方法（多核核磁共振、质谱、元素分析）研究了这些配体与金阳离子的络合性质。对所有分离得到的木糖苷金（III）配合物的生物学性质（抗菌和抗肿瘤）进行了体外研究。木糖苷金（III）配合物对大肠杆菌的活性最高（相对于铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌）。该研究还表明，糖的性质在决定抗菌作用的选择性方面可能起重要作用。初步的抗肿瘤评估表明，一种含有多胺链的配合物对乳腺癌细胞系MDA-MB-231和BT-20表现出有趣的抗增殖活性。该配合物的抗迁移作用还显示，在相同的两种癌细胞系上，细胞迁移平均减少了35%。
