Al-Qassab Zahraa M, Ahmed Osman, Kannan Vaishnavi, Ullah Najeeb, Geddada Sunitha, Ibrahiam Amir T, Nwosu Marcellina
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
General Surgery Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2024 Sep 18;16(9):e69652. doi: 10.7759/cureus.69652. eCollection 2024 Sep.
This literature review explores the association between iron deficiency anemia and migraines, examining their prevalence, underlying pathophysiology, and therapeutic potential of iron supplementation in managing migraine symptoms. A systematic search across major academic databases, including PubMed, Google Scholar, ScienceDirect, and Science.gov, identified relevant peer-reviewed studies that focus on the link between iron deficiency anemia and migraines. The review highlights a higher prevalence of iron deficiency anemia among migraine sufferers, particularly women, with several studies indicating a significant inverse relationship between serum ferritin levels and migraine severity. The findings suggest that low iron levels may exacerbate migraine symptoms, and iron supplementation has been shown to reduce the frequency and intensity of migraines, especially in patients with confirmed iron deficiency anemia. The review also discusses the unique susceptibility of women, particularly those of reproductive age, to both iron deficiency anemia and migraines, emphasizing the importance of gender-specific approaches in treatment. Moreover, the potential impact of iron deficiency on neurovascular function and its contribution to migraine pathogenesis is explored, reinforcing the need for comprehensive management strategies that include nutritional interventions. While iron supplementation appears to be a promising therapeutic option, further research is required to fully understand its long-term effects and to refine treatment protocols to avoid the risks associated with iron overload. This review underscores the significance of addressing nutritional deficiencies as part of a holistic approach to migraine management, offering insights into potential avenues for improving patient outcomes.
本综述探讨缺铁性贫血与偏头痛之间的关联，研究它们的患病率、潜在病理生理学以及补充铁剂在缓解偏头痛症状方面的治疗潜力。通过对包括PubMed、谷歌学术、ScienceDirect和Science.gov在内的主要学术数据库进行系统检索，确定了关注缺铁性贫血与偏头痛之间联系的相关同行评审研究。该综述强调偏头痛患者，尤其是女性中缺铁性贫血的患病率较高，多项研究表明血清铁蛋白水平与偏头痛严重程度之间存在显著的负相关关系。研究结果表明，铁水平低可能会加重偏头痛症状，补充铁剂已被证明可以减少偏头痛的发作频率和强度，尤其是在确诊为缺铁性贫血的患者中。该综述还讨论了女性，尤其是育龄女性对缺铁性贫血和偏头痛的独特易感性，强调了针对性别治疗方法的重要性。此外，还探讨了缺铁对神经血管功能的潜在影响及其对偏头痛发病机制的作用，强化了包括营养干预在内的综合管理策略的必要性。虽然补充铁剂似乎是一种有前景的治疗选择，但需要进一步研究以充分了解其长期影响，并完善治疗方案以避免与铁过载相关的风险。本综述强调解决营养缺乏问题作为偏头痛整体管理方法一部分的重要性，为改善患者预后的潜在途径提供了见解。
