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操作相关因素和患者相关因素在硬膜穿刺后头痛中发挥着不同作用。

Procedural and patient-related factors play differential roles in postdural puncture headache.

作者信息

Yanik Ece, Vuralli Doğa, Tunç Tuğba

机构信息

Department of Neurology and Algology, Faculty of Medicine, Gazi University, Ankara, Turkiye.

Neuropsychiatry Center, Gazi University, Ankara, Turkiye.

出版信息

Turk J Med Sci. 2025 Jan 26;55(2):432-442. doi: 10.55730/1300-0144.5987. eCollection 2025.

Abstract

BACKGROUND/AIM: The incidence of postdural puncture headache varies depending on the multifactorial nature of the risk factors. Patient-related and procedure-related risk factors are still controversial. In this prospective observational study, we aimed to evaluate the risk factors for postdural puncture headache, the effect of previous headache features on the development of postdural puncture headache, and the risk factors for the immediate or delayed postdural puncture headache.

MATERIALS AND METHODS

We prospectively analyzed 116 patients who underwent lumbar puncture for diagnostic or therapeutic purposes. All clinical and laboratory findings, previous headache history, and the features and information related to the lumbar puncture procedure were evaluated.

RESULTS

We found that the presence of longer and more frequent attacks, independent of the type of the prior headache, and a history of migraine accompanied by osmophobia are independent risk factors for postdural puncture headache. A lower volume of cerebrospinal fluid collected, higher frequency of previous headache attacks, diagnosis of idiopathic intracranial hypertension, and acetazolamide use were risk factors for the immediate-onset postdural puncture headache.

CONCLUSION

This is the first study to detail the previous headache features in the development of postdural puncture headache and to extensively examine the risk factors for immediate and delayed postdural puncture headache. It was shown for the first time that patient-related factors may be more important in terms of the development of postdural puncture headache, and procedure-related factors gain importance in terms of its time of occurrence.

摘要

背景/目的:因危险因素具有多因素性质,硬膜穿刺后头痛的发生率各不相同。患者相关和操作相关的危险因素仍存在争议。在这项前瞻性观察研究中,我们旨在评估硬膜穿刺后头痛的危险因素、既往头痛特征对硬膜穿刺后头痛发生的影响,以及硬膜穿刺后即刻或延迟头痛的危险因素。

材料与方法

我们前瞻性分析了116例因诊断或治疗目的接受腰椎穿刺的患者。评估了所有临床和实验室检查结果、既往头痛病史以及与腰椎穿刺操作相关的特征和信息。

结果

我们发现,发作时间更长、更频繁,与既往头痛类型无关,以及伴有畏光症状的偏头痛病史是硬膜穿刺后头痛的独立危险因素。采集的脑脊液量较少、既往头痛发作频率较高、特发性颅内高压的诊断以及使用乙酰唑胺是硬膜穿刺后即刻头痛的危险因素。

结论

这是第一项详细阐述既往头痛特征在硬膜穿刺后头痛发生中的作用,并广泛研究硬膜穿刺后即刻和延迟头痛危险因素的研究。首次表明,在硬膜穿刺后头痛的发生方面,患者相关因素可能更为重要,而在其发生时间方面,操作相关因素更为重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4864/12058012/da455598b8b0/tjmed-55-02-432f1.jpg

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