Department of Medical Oncology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China.
Front Immunol. 2024 Feb 13;15:1337478. doi: 10.3389/fimmu.2024.1337478. eCollection 2024.
Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage. This modification plays a crucial role in the regulation protein localization, accumulation, secretion, stability, and function. Dysregulation of protein S-palmitoylation can disrupt cellular pathways and contribute to the development of various diseases, particularly cancers. Aberrant S-palmitoylation has been extensively studied and proven to be involved in tumor initiation and growth, metastasis, and apoptosis. In addition, emerging evidence suggests that protein S-palmitoylation may also have a potential role in immune modulation. Therefore, a comprehensive understanding of the regulatory mechanisms of S-palmitoylation in tumor cells and the tumor immune microenvironment is essential to improve our understanding of this process. In this review, we summarize the recent progress of S-palmitoylation in tumors and the tumor immune microenvironment, focusing on the S-palmitoylation modification of various proteins. Furthermore, we propose new ideas for immunotherapeutic strategies through S-palmitoylation intervention.
蛋白质 S-棕榈酰化是一种可逆的翻译后脂质修饰，涉及通过硫酯键将 16 个碳的棕榈酰基添加到蛋白质半胱氨酸残基上。这种修饰在调节蛋白质定位、积累、分泌、稳定性和功能方面起着至关重要的作用。蛋白质 S-棕榈酰化的失调会破坏细胞途径，并导致各种疾病的发展，特别是癌症。异常的 S-棕榈酰化已被广泛研究，并被证明参与肿瘤的起始和生长、转移和细胞凋亡。此外，新出现的证据表明，蛋白质 S-棕榈酰化在免疫调节中也可能具有潜在作用。因此，全面了解肿瘤细胞和肿瘤免疫微环境中 S-棕榈酰化的调节机制对于提高我们对这一过程的理解至关重要。在这篇综述中，我们总结了 S-棕榈酰化在肿瘤和肿瘤免疫微环境中的最新进展，重点介绍了各种蛋白质的 S-棕榈酰化修饰。此外，我们通过 S-棕榈酰化干预提出了免疫治疗策略的新想法。
