Wahab Rida, Ahad Abdul, Rahman Haseeb Ur, Fatimi Asad Saulat, Iqbal Sara, Mahmood Faisal, Fatimi Saulat Hasnain
Aga Khan University Hospital, Karachi, Pakistan.
Respir Med Case Rep. 2024 Sep 24;52:102121. doi: 10.1016/j.rmcr.2024.102121. eCollection 2024.
Rhodococcus is an extremely rare, gram positive, aerobic, coccobacillary organism, usually found in the soil or in dairy and livestock animals. It is most commonly affecting the immunocompromised. Only 15 % of cases have been reported in immunocompetent hosts.
We bring forth the unusual case of a 45-year-old gem minor who had already undergone pericardial window due to pericardial effusion. He presented to us with recurrent pericardial effusion and anterior mediastinal mass diagnosed on Computed Tomography Pulmonary Angiogram scan. He was diagnosed with Rhodococcus as being the causative organism of the condition on pericardial fluid cultures. This is an extremely rare manifestation of Rhodococcus infection, which has not yet been reported in literature to the best of our knowledge.
The first human case of Rhodococcus was reported in a young male upon steroidal therapy for autoimmune hepatitis who developed pneumonia in 1967. Rhodococci infections are usually common in immunocompromised hosts, and only 19 cases have been reported in immunocompetent hosts till now. The usual signs of presentation are cough, pleuritic chest pain, and fever; however, it varies according to the site of infection. The most common manifestation is pneumonia, although other presentations include osteomyelitis, brain abscess, wound infections, etc.
The diagnosis and treatment of Rhodococci is very difficult due to the rarity of presentation. Despite that, surgical intervention should be considered as the preferred modality for diagnostic purposes and in infections resistant to medical management.
红球菌是一种极其罕见的革兰氏阳性需氧球杆菌,通常存在于土壤以及奶牛和家畜中。它最常感染免疫功能低下者。据报道,仅15%的病例发生在免疫功能正常的宿主中。
我们介绍了一名45岁宝石矿工的罕见病例,该患者因心包积液已接受心包开窗术。他因复发性心包积液和计算机断层扫描肺动脉造影扫描诊断出的前纵隔肿块前来就诊。心包液培养确诊红球菌为该病的病原体。据我们所知,这是红球菌感染极为罕见的表现,尚未见文献报道。
1967年,首例人类红球菌病例报告于一名接受甾体类药物治疗自身免疫性肝炎的年轻男性,该患者随后患上肺炎。红球菌感染通常在免疫功能低下的宿主中常见,迄今为止,免疫功能正常的宿主中仅报告了19例。常见的症状表现为咳嗽、胸膜炎性胸痛和发热;然而,症状会因感染部位而异。最常见的表现是肺炎,不过其他表现还包括骨髓炎、脑脓肿、伤口感染等。
由于病例罕见,红球菌的诊断和治疗非常困难。尽管如此,手术干预应被视为诊断的首选方式以及用于治疗对药物治疗耐药的感染。