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来自4000年前伊朗人类骨骼中的结核病

Tuberculosis in Human Bones from 4000 Years Ago, Iran.

作者信息

Farhud Dariush D, Azari Mahsa, Rahbar Mehdi

机构信息

School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Research Center for Paleogenomics, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Public Health. 2024 Sep;53(9):2103-2112. doi: 10.18502/ijph.v53i9.16463.

Abstract

BACKGROUND

Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which is a contagious and infectious disease; in the first stage, it destroys the lungs and in the next stage other body organs, such as the spine and long bones. This disease is transmitted through an infected person and due to the weakness of the immune system, the infection intensifies. Tuberculosis has two stages: low activity and high activity. In this article, we have discussed the signs of tuberculosis destruction with high intensity on the bones of prehistory human remains.

METHODS

The examples of our research are related to human remains from the ancient cemetery of 4000 years ago from Sagezabad region of Qazvin Province of Iran. That period of history coincides with the Iron Age 2 and 3 in the region. People inside the Sagezabad cemetery were very near to early urban (the late rural) society.

RESULTS

By matching the form of bone destruction with international atlases for tuberculosis, we have reached a satisfactory result in this article. Due to the strong penetration of the infection into the bones, destruction in the remains was high, so it has simplified the diagnosis for us.

CONCLUSION

We found tuberculosis among the bones. This common ancient disease existed even among Neanderthals.

摘要

背景

结核病由一种名为结核分枝杆菌的细菌引起,是一种具有传染性的疾病;在第一阶段,它会破坏肺部,在接下来的阶段会侵袭其他身体器官,如脊柱和长骨。这种疾病通过感染者传播,并且由于免疫系统的薄弱,感染会加剧。结核病有两个阶段:低活性和高活性。在本文中,我们讨论了高强度结核病对史前人类遗骸骨骼的破坏迹象。

方法

我们的研究样本来自伊朗加兹温省萨盖扎巴德地区4000年前的古代墓地中的人类遗骸。那段历史时期与该地区的铁器时代2和3相吻合。萨盖扎巴德墓地内的人们非常接近早期城市(晚期乡村)社会。

结果

通过将骨骼破坏形式与国际结核病图谱进行比对,我们在本文中取得了令人满意的结果。由于感染对骨骼的强烈侵袭,遗骸中的破坏程度很高,这为我们的诊断提供了便利。

结论

我们在骨骼中发现了结核病。这种常见的古老疾病甚至在尼安德特人中也存在。

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