Helwig E B, May D
Cancer. 1986 Jan 15;57(2):368-76. doi: 10.1002/1097-0142(19860115)57:2<368::aid-cncr2820570230>3.0.co;2-n.
Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulcernodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior and metastasis are vascular invasion, recurrence, deep tissue invasion, tumor necrosis and, possibly, defective or depressed host resistance. The metastasizing primary AFX were located on the head, and the metastasis involved the structures in the region of the parotid gland.
皮肤非典型纤维黄色瘤（AFX）发生于老年人，表现为头颈部受光化损伤皮肤处的小结节或溃疡结节。绝大多数AFX呈良性表现，转移罕见。本文报告了8例转移性AFX。预示侵袭性生物学行为和转移的因素包括血管侵犯、复发、深部组织侵犯、肿瘤坏死，可能还有宿主抵抗力缺陷或低下。转移性原发性AFX位于头部，转移累及腮腺区域的结构。
