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双（吡唑基）甲烷配体支持的新型铀酰簇合物的合成与表征：仿生催化氧化、牛血清白蛋白蛋白质相互作用及细胞毒性研究

Synthesis and characterization of novel uranyl clusters supported by bis(pyrazolyl) methane ligands: biomimetic catalytic oxidation, BSA protein interaction and cytotoxicity studies.

作者信息

S Nakul, R Bhagavathish, Kulkarni Naveen V, Patil Ajeetkumar, Arakera Suresh B, John Sam

机构信息

Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri 690525 Kollam Kerala India

Department of Atomic and Molecular Physics, Manipal Academy of Higher Education (MAHE) Manipal 576 104 Karnataka India

出版信息

RSC Adv. 2024 Oct 17;14(45):32802-32817. doi: 10.1039/d4ra06347c.

DOI:10.1039/d4ra06347c
PMID:39429924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11484172/
Abstract

Two novel uranyl complexes were synthesized using bis-pyrazolyl methane ligands. The complexes were characterized by several spectroscopic techniques, including UV-Vis, IR, NMR, mass spectrometry, fluorescence, electrochemical, and thermogravimetric analysis. The solid-state structure of the complex C1 was determined with the help of single-crystal X-ray diffraction studies. The complexes C1 and C2 efficiently catalyse the oxidation of 3,5-di--butyl catechol and 2-aminophenol in the atmospheric air, imitating the catalytic activity of the catechol oxidase and phenoxazinone synthase enzymes. The kinetic parameters and the catalytic efficiency ( / ) of the reactions were calculated. Formation of organic free radicals in the catalytic reactions was confirmed by EPR spectroscopy. The interaction of these complexes with the protein, bovine serum albumin, was investigated by using UV-Vis and fluorescence spectral analysis. The cytotoxicity of the complexes against MDAMB-231 and A549 cell lines was investigated, and IC values were determined.

摘要

使用双吡唑基甲烷配体合成了两种新型铀酰配合物。通过多种光谱技术对这些配合物进行了表征，包括紫外可见光谱、红外光谱、核磁共振光谱、质谱、荧光光谱、电化学和热重分析。借助单晶X射线衍射研究确定了配合物C1的固态结构。配合物C1和C2在大气中有效地催化3,5-二叔丁基邻苯二酚和2-氨基苯酚的氧化反应，模拟了儿茶酚氧化酶和吩恶嗪酮合酶的催化活性。计算了反应的动力学参数和催化效率（kcat/KM）。通过电子顺磁共振光谱证实了催化反应中有机自由基的形成。利用紫外可见光谱和荧光光谱分析研究了这些配合物与蛋白质牛血清白蛋白的相互作用。研究了配合物对MDAMB-231和A549细胞系的细胞毒性，并测定了IC值。

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