Pressman P I
Cancer. 1986 Feb 1;57(3):577-80. doi: 10.1002/1097-0142(19860201)57:3<577::aid-cncr2820570330>3.0.co;2-j.
The bilaterality of breast cancer detected by performing a contralateral biopsy has been reported to be 14%. Since the majority of cancers detected were noninfiltrating, a mastectomy was not always performed because of either the advanced stage of the presenting carcinoma or the age of the patient. This study was undertaken to determine the yield of contralateral cancers in younger patients with a better prognosis. Patients younger than 65 years with clinical Stage I and II initial breast cancers were selected for biopsy of the opposite breast between September 1978 and December 1984. Of 651 consecutive patients treated for breast cancer, 610 had an initial breast cancer and 258 (42%) met the criteria. Forty-three contralateral primary breast cancers were detected, for an incidence of 16.7%. In 11 of these 43 patients there was suspicion that a malignancy might be present; these were all infiltrating carcinomas. In 32 patients a truly random biopsy was performed, and the yield was 14.2%. Four (12.5%) of these were infiltrating cancers, and 28 (87.5%) were in situ carcinomas. By selecting patients for biopsy of the opposite breast, a 16.7% incidence of cancers can be detected. Since these patients were younger than 65 years and have a good prognosis in terms of their initial breast cancer, biopsy of the opposite breast is a worthwhile procedure and should be performed with the hope of improving these patients' ultimate outcome.
据报道，通过对侧活检检测出的双侧乳腺癌发生率为14%。由于检测出的大多数癌症为非浸润性，因现有癌处于晚期或患者年龄因素，并非总是进行乳房切除术。本研究旨在确定预后较好的年轻患者对侧癌的检出率。选取1978年9月至1984年12月期间临床分期为I期和II期的初始乳腺癌且年龄小于65岁的患者进行对侧乳房活检。在651例连续接受乳腺癌治疗的患者中，610例患有初始乳腺癌，258例（42%）符合标准。检测出43例对侧原发性乳腺癌，发生率为16.7%。在这43例患者中，有11例怀疑可能存在恶性肿瘤；这些均为浸润性癌。对32例患者进行了真正的随机活检，检出率为14.2%。其中4例（12.5%）为浸润性癌，28例（87.5%）为原位癌。通过选择患者进行对侧乳房活检，可检测出16.7%的癌症发生率。由于这些患者年龄小于65岁，且就其初始乳腺癌而言预后良好，对侧乳房活检是一项值得进行的操作，应进行该操作以期改善这些患者的最终结局。
