Klein Johanna M A, Runge Isabel, Pannen Ann-Katrin, Wakuma Tariku, Abera Semaw Ferede, Adissie Adamu, Unverzagt Susanne, Schmitt Markus, Waterboer Tim, Höfler Daniela, Thomssen Christoph, Kantelhardt Eva Johanna
Department of Gynaecology, Martin Luther University Halle-Wittenberg, Halle (Saale) 06097, Germany.
Global Health Working Group, Martin Luther University Halle-Wittenberg, Halle (Saale) 06097, Germany.
Ecancermedicalscience. 2024 Sep 30;18:1783. doi: 10.3332/ecancer.2024.1783. eCollection 2024.
Sexually transmitted infections (STIs) and human papillomavirus (HPV) infections are common among women of reproductive age and can lead to infertility, adverse pregnancy outcomes, neonatal infections and cervical cancer. In countries with limited medical coverage, untreated infections contribute to high morbidity. This study aimed to expand the current knowledge on the prevalence of bacterial vaginosis (BV) and STIs in pregnant Ethiopian women and assess the association of these conditions with HPV infections. Socio-demographic data and vaginal lavage samples were collected from 779 asymptomatic women aged 18 to 45 years (median age, 25.9 years) attending antenatal care in seven centres across Ethiopia. Multiplex polymerase chain reaction was used to test for BV, , , , herpes simplex virus types 1 and 2 (HSV-1/2), , , and HPV. Overall, 26.8% (95% confidence interval (CI): 23.7-29.9) of women tested positive for BV or one of the following STIs: , , , , HSV-1/2 or . Additionally, 22.1% tested positive for at least one high-risk HPV type. and HSV-2 were significantly more common among women who were positive for HPV and high-risk HPV. This study reveals a high prevalence of asymptomatic pregnant women who are positive for BV, STIs or HPV, putting them at risk of adverse pregnancy outcomes, secondary infertility or cervical cancer in a country with limited medical coverage. Screening and treating these women could be crucial in reducing morbidity.
性传播感染（STIs）和人乳头瘤病毒（HPV）感染在育龄妇女中很常见，可导致不孕、不良妊娠结局、新生儿感染和宫颈癌。在医疗覆盖有限的国家，未经治疗的感染导致高发病率。本研究旨在扩大目前关于埃塞俄比亚孕妇细菌性阴道病（BV）和性传播感染患病率的知识，并评估这些情况与HPV感染的关联。从埃塞俄比亚七个中心接受产前护理的779名18至45岁（中位年龄25.9岁）无症状妇女中收集社会人口统计学数据和阴道灌洗样本。采用多重聚合酶链反应检测BV、[此处原文缺失部分病原体名称]、单纯疱疹病毒1型和2型（HSV-1/2）、[此处原文缺失部分病原体名称]和HPV。总体而言，26.8%（95%置信区间（CI）：23.7 - 29.9）的妇女BV或以下性传播感染之一检测呈阳性：[此处原文缺失部分病原体名称]、HSV-1/2或[此处原文缺失部分病原体名称]。此外，22.1%的妇女至少一种高危HPV类型检测呈阳性。[此处原文缺失部分病原体名称]和HSV-2在HPV和高危HPV呈阳性的妇女中明显更常见。本研究揭示了在医疗覆盖有限的国家，BV、性传播感染或HPV呈阳性的无症状孕妇患病率很高，使她们面临不良妊娠结局、继发性不孕或宫颈癌的风险。对这些妇女进行筛查和治疗对于降低发病率可能至关重要。
