de Oliveira Thais Cabral, Bispo Guilherme Andraus, Poleto Laura Beatriz de Socorro, Martinez Francisco Dantas de Maio, de Souza Max Túlio Rocha, Linhares Lais Calazans Menescal, Taffarel Marilda Onghero, Ferreira Wagner Luís, Dos Santos E Paulo Sérgio Patto
São Paulo State University (UNESP), School of Veterinary Medicine of Araçatuba (FMVA), Araçatuba, São Paulo, Brazil.
São Paulo State University (UNESP), School of Agricultural and Veterinary Sciences (FCAV), Jaboticabal, Brazil.
Vet Med Int. 2024 Oct 12;2024:5541917. doi: 10.1155/2024/5541917. eCollection 2024.
Propofol is an intravenous anesthetic administered as a bolus or continuous infusion during anesthetic induction and maintenance. Its pharmacokinetic characteristics include hepatic and extrahepatic metabolism with a rapid onset of action and short duration, which provides a smooth anesthetic induction without excitatory effects. To evaluate whether the isolated use of propofol in anesthetic induction in dogs changes the hemodynamic variables assessed via echocardiography. Prospective clinical study. Twelve healthy dogs. The dogs were induced with propofol (dose/effect) at 3 mg/kg/minute, and echocardiographic evaluations were performed immediately before anesthetic induction (MB) and immediately after its interruption (MI), at the end of the supply of the anesthetic agent. A significant reduction was observed between the values of the following hemodynamic variables: Ejection Fraction (EF%), which varied from 70% to 65% (=0.011) between moments, and the Doppler Ejection Index (DEI), which ranged from 27.1 mL/beat/m to 22.4 mL/beat/m (=0.044). The heart rate (HR) and the other studied hemodynamic variables showed no significant differences between the evaluated moments. Propofol was a safe anesthetic-inducing agent, maintaining stable hemodynamic indices during anesthetic induction at the used rate.
丙泊酚是一种静脉麻醉剂，在麻醉诱导和维持期间以推注或持续输注的方式给药。其药代动力学特征包括肝内和肝外代谢，起效迅速且持续时间短，能提供平稳的麻醉诱导且无兴奋作用。为评估在犬类麻醉诱导中单独使用丙泊酚是否会改变通过超声心动图评估的血流动力学变量。前瞻性临床研究。选取12只健康犬只。犬只以3毫克/千克/分钟的丙泊酚（剂量/效应）进行诱导，并在麻醉诱导前即刻（MB）、麻醉剂供应结束后中断麻醉即刻（MI）进行超声心动图评估。观察到以下血流动力学变量值之间有显著降低：射血分数（EF%），不同时刻之间从70%变化至65%（=0.011）；多普勒射血指数（DEI）从27.1毫升/搏/米变化至22.4毫升/搏/米（=0.044）。心率（HR）以及其他研究的血流动力学变量在评估时刻之间无显著差异。丙泊酚是一种安全的麻醉诱导剂，以所用速率进行麻醉诱导期间能维持稳定的血流动力学指标。
