Fan Xiwei, Ong Louis Jun Ye, Sun Antonia RuJia, Prasadam Indira
Department of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
School of Mechanical, Medical & Process Engineering, Queensland University of Technology, Brisbane, Australia.
J Orthop Translat. 2024 Oct 4;49:62-73. doi: 10.1016/j.jot.2024.09.004. eCollection 2024 Nov.
Cell polarity refers to the orientation of tissue and organelles within a cell and the direction of its function. It is one of the most critical characteristics of metazoans. The development, growth, and functional tissue distribution are closely related to holistic tissue or organ homeostasis. However, the connection between cell polarity and osteoarthritis (OA) is less well-known. In OA, multiple chondrocyte clusters and tissue disorganisation can be observed in the degraded cartilage tissue. The excessive upregulation of the planar cell polarity (PCP) signalling pathway leads to the loss of cell polarity and organisation in OA progression and aetiology. Recent research has become increasingly aware of the importance of cell polarity and its correlation with OA. Several cell polarity-related treatments have shed light on OA. A thorough understanding of cell polarity and OA would provide more insights for future investigations to treat this worldwide disease.
Understanding cell polarity, associated signalling pathways, organelle changes, and cell movement in the development of OA could lead to advances in precision medicine and enhanced treatment strategies for OA patients.
细胞极性是指细胞内组织和细胞器的定向及其功能方向。它是后生动物最关键的特征之一。发育、生长和功能性组织分布与整体组织或器官的稳态密切相关。然而，细胞极性与骨关节炎（OA）之间的联系鲜为人知。在OA中，在退化的软骨组织中可观察到多个软骨细胞簇和组织紊乱。平面细胞极性（PCP）信号通路的过度上调导致OA进展和病因学中细胞极性和组织的丧失。最近的研究越来越意识到细胞极性的重要性及其与OA的相关性。几种与细胞极性相关的治疗方法为OA带来了曙光。全面了解细胞极性和OA将为未来治疗这种全球性疾病的研究提供更多见解。
了解OA发展过程中的细胞极性、相关信号通路、细胞器变化和细胞运动，可能会推动精准医学的进步，并增强针对OA患者的治疗策略。
