Tao Biao, Gu Dian, Wang Kai, Li Yinan, Xu Xianlin, Chen Jiexun
Department of Urology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 211100, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Oct 16;17:3795-3802. doi: 10.2147/DMSO.S479665. eCollection 2024.
Metabolic syndrome (MetS) is associated with the development of several diseases. However, the correlation between MetS and size of renal cysts remains unclear. This research aims to explore the potential connection between them, offering theoretical guidance for clinical prevention and treatment of renal cysts.
A total of 467 patients diagnosed with renal cysts and admitted to Sir Run Run Hospital, Nanjing Medical University from September 2019 to September 2020 were eventually included in this study. They were divided into the small cyst group (cyst volume≤1.5cm³) and the large cyst group (cyst volume>1.5cm³) based on the median value of cyst volume. Multivariate logistic regression analysis was used to evaluate the association between MetS and size of renal cysts.
Our results indicated that MetS (OR 1.941, 95% CI 1.286-2.927, =0.002) was positively associated with the size of renal cysts. Additionally, multiple renal cysts (OR 2.259, 95% CI 1.402-3.640, =0.001) and serum globulin (OR 0.945, 95% CI 0.905-0.987, =0.011) were positively and negatively related to size of renal cysts, respectively.
Our study reveals the association between MetS and the size of renal cysts. Patients with MetS are more likely to have larger renal cysts. The administration of MetS may help limit the development of renal cysts. Further prospective studies are needed to explore the causal relationship between MetS and renal cysts.
代谢综合征（MetS）与多种疾病的发生相关。然而，MetS与肾囊肿大小之间的相关性仍不清楚。本研究旨在探讨它们之间的潜在联系，为肾囊肿的临床防治提供理论指导。
最终纳入2019年9月至2020年9月在南京医科大学附属逸夫医院确诊为肾囊肿并入院的467例患者。根据囊肿体积的中位数将其分为小囊肿组（囊肿体积≤1.5cm³）和大囊肿组（囊肿体积>1.5cm³）。采用多因素logistic回归分析评估MetS与肾囊肿大小之间的关联。
我们的结果表明，MetS（OR 1.941，95%CI 1.286-2.927，P=0.002）与肾囊肿大小呈正相关。此外，多发性肾囊肿（OR 2.259，95%CI 1.402-3.640，P=0.001）和血清球蛋白（OR 0.945，95%CI 0.905-0.987，P=0.011）分别与肾囊肿大小呈正相关和负相关。
我们的研究揭示了MetS与肾囊肿大小之间的关联。患有MetS的患者更有可能有较大的肾囊肿。控制MetS可能有助于限制肾囊肿的发展。需要进一步的前瞻性研究来探讨MetS与肾囊肿之间的因果关系。
